The functions and efficacy of Bedaquiline tablets

Bedaquiline tablets (Bedaquiline) is an anti-tuberculosis drug. As a new type of drug, it has a special mechanism of action and wide clinical application. The functions and efficacy of bedaquiline tablets will be introduced in detail below.

1.Mechanism of action: Bedaquiline tablets work by inhibiting ATP synthase during the cell wall synthesis of Mycobacterium tuberculosis. ATPSynthase is a key enzyme in tuberculosis cells and participates in the energy metabolism process of bacteria. Bedaquiline tablets can bind to the ATPsynthase subunitc in the bacterial cell wall, blocking the normal function of the enzyme, causing the bacteria to be unable to carry out normal energy metabolism and growth and replication, thereby producing a bactericidal effect on Mycobacterium tuberculosis.

2.Anti-tuberculosis effect: The main efficacy of bedaquiline tablets is to treat pulmonary tuberculosis, especially multidrug-resistant tuberculosis (MDR-TB). Multidrug-resistant tuberculosis refers to tuberculosis that is resistant to multiple conventional anti-tuberculosis drugs and for which traditional treatments are less effective. As a new anti-tuberculosis drug, bedaquiline tablets can significantly improve the treatment success rate and cure rate of multidrug-resistant tuberculosis.

3.The key drug in the treatment of multidrug-resistant tuberculosis: Bedaquiline tablets are included in the comprehensive treatment plan for multidrug-resistant tuberculosis and are usually used in combination with other anti-tuberculosis drugs to improve the treatment effect and success rate. Its application in the treatment of multidrug-resistant tuberculosis has the following characteristics:

Bactericidal effect: Bedaquiline tablets can directly kill drug-resistant strains and reduce the load of tuberculosis bacteria.

Shorten treatment time: Compared with traditional treatment options, the addition of bedaquiline tablets can shorten treatment time and reduce the patient's treatment burden.

Improve treatment success rate: Clinical trials have shown that the treatment success rate of multidrug-resistant tuberculosis patients using bedaquiline tablets is significantly improved, reducing the risk of disease recurrence and transmission.

4.Prevention of relapse after drug-resistant tuberculosis treatment: The use of bedaquiline tablets can help reduce the risk of relapse after drug-resistant tuberculosis is cured. Relapse of TB is a serious condition that not only increases the patient's suffering but also increases the risk of disease transmission. The bactericidal effect of bedaquiline tablets can reduce the survival of drug-resistant strains, thereby reducing the probability of recurrence and increasing the long-term stability of cure.

5.Control the spread of tuberculosis: Tuberculosis is a highly contagious disease that is easily spread in communities and medical institutions. The use of bedaquiline tablets can reduce the risk of transmission of tuberculosis bacteria. By reducing the number and load of drug-resistant strains, bedaquiline tablets help control the spread of the disease and reduce the spread of tuberculosis bacteria.

6.Medication for special populations: Bedaquiline tablets are also suitable for the treatment of special populations, including children and adolescents, pregnant women and wet nurses. Clinical studies on these special groups have shown that bedaquiline tablets have good performance in terms of safety and efficacy.

It should be noted that the use of bedaquiline tablets should be carried out under the guidance of a professional doctor, and the doctor's prescription and medication instructions should be strictly followed. Patients should receive regular monitoring and follow-up from their doctors to ensure the safety and effectiveness of treatment. If you have any questions or discomforts, patients should promptly consult a physician or professional medical provider for accurate advice and guidance.

Bedaquiline tablets have been launched in China and have been included in Class B medical insurance. Patients can buy it domestically, but the price is very high. The price of 100mg*24tablets is around 15,000 yuan. For specific prices, please consult the local hospital pharmacy. There are only original drugs abroad, and the more cost-effective ones are Russian original drugs. The price of 100mg*188 tablets is also about 15,000 yuan. The specifications are about 8 times that of domestic ones. Relatively speaking, the price is still very cheap compared to domestic ones. And the ingredients of domestic and foreign original drugs are consistent.