How to take tucatinib

The recommended dose of tucatinib for the treatment of adult patients with advanced unresectable or metastatic colorectal cancer is 300 mg orally twice daily, which may be combined with other drugs (such as trastuzumab, capecitabine) until disease progression or unacceptable toxicity occurs. If the patient vomits or misses a dose of tucatinib, take the next dose at the usually scheduled time.

For adverse reactions (such as diarrhea, liver toxicity, etc.) after using tucatinib, the dose should be reduced to 250 mg orally twice a day for the first time, 200 mg orally twice a day for the second time, and 150 mg orally twice a day for the third time. Patients who cannot tolerate 150 mg orally twice a day should permanently discontinue tucatinib. Patients with severe hepatic impairment have the recommended dose reduced to 200 mg orally twice daily.

It is understood that the original drug Tucatinib has not yet been launched in China, so it has not entered the scope of domestic medical insurance. Patients in need cannot yet purchase this drug in pharmacies or hospitals. The price of the European version of tucatinib original drug sold overseas is around RMB 72,000 (the price may fluctuate due to exchange rates), which is expensive. There are also generic drugs of tucatinib produced in other countries. The price of Tucatinib produced by a Lao pharmaceutical factory is around 6,400 yuan (the price may fluctuate due to the exchange rate). The price is much cheaper than the original drug, and the ingredients of foreign generic drugs are basically the same as the original drug.