How much does a box of tucatinib cost?

By inhibiting tyrosine kinases, tucatinib exerts anti-tumor activity and can reduce the size of HER-2-positive breast cancer tumors. In clinical trials, the combination of tucatinib and trastuzumab showed enhanced activity in vitro and in vivo compared with either agent administered alone.

Mutations in the HER-2 gene are seen in certain types of breast cancer Tucatinib inhibits the tyrosine kinase of the HER-2 gene. Mutations in the tyrosine kinase in the HER-2 gene lead to a cascade of increased cell signaling and proliferation, leading to malignancy. In vitro study results indicate that tucatinib inhibits the phosphorylation of HER-2 and HER-3, leading to downstream changes in MAPK and AKT signaling and cell proliferation. Cells expressing HER-2 have anti-tumor activity. In vivo, tucatinib may inhibit HER-2-expressing tumors via the same mechanism.

It is understood that the original drug Tucatinib has not yet been launched in China, so it has not entered the scope of domestic medical insurance. Patients in need cannot yet purchase this drug in pharmacies or hospitals. The price of the European version of tucatinib original drug specifications150mg*60 tablets per box listed overseas is around RMB 72,000 (the price may fluctuate due to exchange rates), which is expensive. There are also generic drugs of Tucatinib produced in other countries. The price of 150mg*60 tablets per box produced by Laos pharmaceutical factory is around 6,400 RMB (the price may fluctuate due to the exchange rate). The price is much cheaper than the original drug, and the ingredients of foreign generic drugs are basically the same as the original drug.