What is the anti-tuberculosis effect of Bedaquiline tablets?

Bedaquiline tablets (Bedaquiline), as a new type of anti-tuberculosis drug, have been proven through clinical trials to have significant anti-tuberculosis effects. The following will introduce the anti-tuberculosis effect of bedaquiline tablets in detail based on the results of relevant clinical trials.

1.Treatment of multidrug-resistant tuberculosis (MDR-TB):

Multidrug-resistant tuberculosis refers to tuberculosis that is resistant to multiple conventional anti-tuberculosis drugs. Conventional treatment regimens are less effective against multidrug-resistant tuberculosis, necessitating the search for new treatment options. Bedaquiline tablets have shown significant efficacy in the treatment of multidrug-resistant tuberculosis.

A multi-center, randomized, double-blind, placebo-controlled clinical trial titled"Conquering Multidrug-Resistant Tuberculosis" studied the efficacy and safety of bedaquiline tablets in the treatment of MDR-TB. The results showed that bedaquiline tablets had a significant improvement in treatment success rate compared with placebo. Treatment success was defined as patients with negative sputum cultures and no recurrence at the end of treatment.

Another study called"Anti-drug-resistant TB Drug Trial" also confirmed the effectiveness of bedaquiline tablets in the treatment of MDR-TB. The study included 521 patients, and the results showed that patients treated with bedaquiline tablets had a significantly better treatment success rate than the control group.

2.Combination therapy with other anti-tuberculosis drugs:

Bedaquiline tablets are usually used as part of a comprehensive treatment regimen, in conjunction with other anti-tuberculosis drugs. The purpose of combination therapy is to enhance efficacy and reduce the risk of survival and recurrence of drug-resistant strains.

One study examined bedaquiline tablets in combination with standard anti-tuberculosis treatment regimens. The results showed that patients who used bedaquiline tablets in combination therapy had a significantly higher treatment success rate than those who only used standard treatment options. This shows that the addition of bedaquiline tablets can significantly improve the therapeutic effect.

3.Reducing the spread of tuberculosis:

Tuberculosis is a highly contagious disease, and the effectiveness of treatment is closely related to controlling transmission. The use of bedaquiline tablets helps reduce the risk of transmission of drug-resistant tuberculosis strains.

According to the results of a study, patients who used bedaquiline tablets had shorter sputum culture-negative times and a lower risk of transmitting tuberculosis bacteria than those who did not. This has important implications for controlling the spread of tuberculosis in communities and health care settings.

Overall, bedaquiline tablets have shown significant anti-tuberculosis effects in clinical trials. It has shown good efficacy in the treatment of multidrug-resistant tuberculosis and can significantly improve the success rate of treatment and reduce the risk of recurrence of drug-resistant strains. In addition, the combined use of bedaquiline tablets and other anti-tuberculosis drugs can enhance the therapeutic effect. The use of bedaquiline tablets also helps reduce the spread of tuberculosis bacteria, thereby having a positive impact on controlling the epidemic of tuberculosis.

However, although bedaquiline tablets have shown good anti-tuberculosis effects in clinical trials, the specific therapeutic effects still vary depending on individual differences and disease conditions. When using bedaquiline tablets, patients should always follow the doctor's instructions and prescriptions, receive regular monitoring and follow-up from the doctor, and promptly report any discomfort or disease progression.

Bedaquiline tablets have been launched in China and have been included in Class B medical insurance. Patients can buy it domestically, but the price is very high. The price of 100mg*24tablets is around 15,000 yuan. For specific prices, please consult the local hospital pharmacy. There are only original drugs abroad, and the more cost-effective ones are Russian original drugs. The price of 100mg*188 tablets is also about 15,000 yuan. The specifications are about 8 times that of domestic ones. Relatively speaking, the price is still very cheap compared to domestic ones. And the ingredients of domestic and foreign original drugs are consistent.