Brigatinib/Brigatinib Medication Instructions

Brigatinib/Brigatinib (Brigatinib) is a drug used to treat certain types of non-small cell lung cancer (NSCLC). The following is a detailed description of Brigatinib/Brigatinib.

1. Indications:Brigatinib/Brigatinib is suitable for the treatment of adult patients with NSCLC who have positive translocation of kinase or are resistant to second-generation kinase inhibitors.

2. Mechanism of action:Brigatinib/Brigatinib is a tyrosine kinase inhibitor that targets tyrosine kinase ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) activity, thereby inhibiting the growth and spread of NSCLC cells.

3. Pharmacology: Brigatinib/Brigatinib binds to ALK and ROS1 to block their active tyrosine kinase, thereby inhibiting the activation of downstream signaling pathways, thereby reducing the proliferation and survival of tumor cells.

4. Dosage and usage: 90mg each time, once/ days for 7 days; if there are no serious side effects or intolerance, 7In the future, increase to 180 mg/ days, once a day; continue taking brigatinib/brigatinib until disease progression or intolerable side effects occur. The patient's liver function and blood pressure should be monitored regularly during treatment, and the dose should be adjusted as needed.

5. Side effects:Common side effects of brigatinib/Brigatinib include nausea, vomiting, diarrhea, fatigue, headache, hypertension, pneumonia, tachycardia, abnormal liver function, etc. Serious side effects may include interstitial lung disease, hyperglycemia, cardiotoxicity, etc. Patients should pay close attention to side effects during medication and report them to their doctors in a timely manner.

6. Warnings and Precautions: When usingbrigatinib/brigatinib, doctors and patients should pay attention to the following matters:

1.Pneumonia: Brigatinib/Brigatinib may cause severe pneumonia. Patients should pay attention to the symptoms of respiratory infection and seek medical treatment in time.

2.Hypertension:Brigatinib/Brigatinib can cause high blood pressure, and patients should monitor their blood pressure regularly and make adjustments as needed.

3.Abnormal liver function:Brigatinib/Brigatinib may cause abnormal liver function, and patients should monitor liver function indicators during treatment.

4.Avoid interactions with other drugs:Brigatinib/Brigatinib may interact with certain drugs. Patients should inform their doctors about other drugs they are taking during medication.

7. Contraindications:Brigatinib/BrigatinibIt is contraindicated in patients with allergic reactions. Additionally, use of brigatinib should be avoided in patients with severe hepatic impairment.

8. Drug interactions:Brigatinib/Brigatinib may interact with certain drugs, including CYP3Ainhibitors, CYP3A inducers, and gastric acid suppressors. Patients should inform their doctor about other drugs they are taking while taking this medication so that the doctor can evaluate potential interactions and adjust the dosage.

9. Medication for special groups:

1.Pregnant and lactating women:Brigatinib/BrigatinibPossibly may cause harm to the fetus or infant, patients should consult their doctor before using brigatinib/brigatinib and follow their doctor's advice.

2.Elderly patients: Elderly patients may be more prone to side effects when using brigatinib/brigatinib, and doctors should adjust the dose based on the patient's overall condition.

3.Children and Adolescents:Brigatinib/The safety and effectiveness of Brigatinibin children and adolescents under 18 years of age have not been established and its use is not recommended.

10. Launch and price situation: Brigatinib/Brigatinib has been launched in China and has been included in medical insurance. Since it has just been approved for marketing, patients may not be able to buy it in domestic pharmacies. If you need to purchase it in China, please consult the local pharmacy. However, the price is quite high, more than 10,000 yuan. Brigatinib abroad/Brigatinib is mainly a generic drug, mainly from Bangladesh and Laos. The price of the international version of the Bangladeshi generic drug Yaopin is about 2000 around 600, and the specifications are 90mg*30 tablets; the price of the Laos version of generic drugs is about 600, and the specifications are smaller. And the ingredients of domestic original drugs and foreign generic drugs are basically the same.

Brigatinib/Brigatinib is a drug used to treat certain types of NSCLC by inhibiting ALK and ROS1The activity of tyrosine kinase, thereby inhibiting the growth and spread of tumor cells. Patients should pay attention to side effects and warnings during medication, and report any discomfort to their doctor in a timely manner. Special groups such as pregnant women, lactating women and elderly patients should use it after consulting a doctor. Interactions with other medications should also be noted. The doctor will decide the dosage and use of brigatinib based on the patient's condition.