Is Brigatinib/Brigatinib a fourth-generation targeted drug?

Brigatinib/Brigatinib (Brigatinib) is considered a second or third-generation ALK (anaplastic lymphoma kinase) targeted drug, rather than a fourth-generation targeted drug.

The fourth generation of targeted drugs refers to drugs that overcome drug resistance and increase efficacy through higher-level targeting design. These drugs often have multiple mechanisms of action, can target multiple kinases or signaling pathways simultaneously, and have stronger inhibitory effects on drug-resistant mutations.

Brigatinib/BrigatinibAlthough it is a highly selective ALK inhibitor, it mainly inhibits the stimulation of ALK The inhibitory effect is relatively low for some common ALK resistance mutations, such as the T790M mutation of ALK. In contrast, fourth-generation ALK inhibitors (such as lorlatinib) are designed to simultaneously inhibit multiple ALK mutants, including drug-resistant mutations, to better address drug resistance issues.

Althoughbrigatinib/brigatinib has shown significant efficacy in the treatment of ALK fusion-positive non-small cell lung cancer (NSCLC), it is still classified as a second or third generation targeted drug. With the continuous advancement of scientific research and technology, the development of fourth-generation targeted drugs is ongoing, aiming to further improve the therapeutic effect and drug resistance of ALK-positive NSCLC.

Brigatinib/BrigatinibIt is already on the market in China and has been included in medical insurance. Since it has just been approved for marketing, patients may not be able to buy it in domestic pharmacies. If you need to purchase it in China, please consult the local pharmacy, but the price is quite high, more than 10,000 yuan. Foreign Brigatinib/Brigatinib are mainly generic drugs, mainly Bangladeshi and Laos generic drugs. The price of the international version of the Bangladeshi generic drug Yaopin is about 2000yuan, the specification is 90mg*30 tablets; the price of the Laos version of the generic drug is about 600, and the specification is smaller. And the ingredients of domestic original drugs and foreign generic drugs are basically the same.