Efficacy and effects of Sorafenib

Sorafenib (Sorafenib) is an oral molecularly targeted therapy drug used to treat various types of cancer, especially renal cell carcinoma, hepatocellular carcinoma and thyroid cancer. Sorafenib exerts antitumor activity by inhibiting multiple signaling pathways. It prevents the progression and spread of tumors by inhibiting processes such as tumor cell growth, proliferation and new blood vessel formation.

Tumor cells need to build new blood vessels to supply nutrients and oxygen. Sorafenib can interfere with the process of tumor angiogenesis and inhibit the activity of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR), thereby reducing the tumor blood supply and preventing the tumor from continuing to grow. Sorafenib also has certain immunomodulatory effects. It can inhibit the activity of tumor-related immunosuppressive cells (such as Treg cells and MDSCs), enhance the activity of immune cells (such as NK cells and CD8+T cells), and promote anti-tumor immune responses.

The original drug of sorafenib has been launched in China and has entered the scope of medical insurance. Different regions have different reimbursement ratios, and the price after reimbursement may vary. SpecificationsThe price of 0.2g*60 tablets may be around 1,200 yuan. The original drug of sorafenib has also been launched overseas, and there are also generic drugs of sorafenib produced in other countries. The price of 0.2g*60 tablets produced by a Bangladesh pharmaceutical factory is around RMB 450 (the price may fluctuate due to the exchange rate). The ingredients of the original drug are basically the same as those of the generic drugs. For specific prices and drug details, please consult the medical consultant of Yaode.