How long does it take to become resistant to Sorafenib?

The rate at which resistance to sorafenib develops varies between individuals and the type of cancer. In general, patients may face challenges with drug resistance when treated with sorafenib. According to research data, about 30-40% of patients with hepatocellular carcinoma (HCC) develop drug resistance within 6 months after using sorafenib. The development of drug resistance may further lead to reduced therapeutic efficacy, tumor progression and recurrence.

Hepatocellular carcinoma (HCC) is a heterogeneous malignant tumor that mainly affects liver cells. Sorafenib is a dual-target inhibitor targeting the serine-threonine kinase Raf and the tyrosine kinase VEGFR/PDGFR. Molecular targeted therapy with sorafenib is currently the main treatment method for advanced HCC, whether it is a single regimen or a combination regimen. However, its effectiveness was observed to be hampered by drug resistance in a large number of patients. HCC is highly heterogeneous within tumors and between individuals, which affects disease progression, classification, prognosis and natural cell susceptibility to drug resistance. Two international randomized controlled trials (RCT) played a key role in the approval of sorafenib for the treatment of advanced HCC, with 602 patients randomized to receive sorafenib or placebo. Compared with the placebo group, the median overall survival was extended by approximately 3 months in the sorafenib treatment group (10.7 vs. 7.9).

The original drug of sorafenib has been launched in China and has entered the scope of medical insurance. Different regions have different reimbursement ratios, and the price after reimbursement may vary. SpecificationsThe price of 0.2g*60 tablets may be around 1,200 yuan. The original drug of sorafenib has also been launched overseas, and there are also generic drugs of sorafenib produced in other countries. The price of 0.2g*60 tablets produced by a Bangladesh pharmaceutical factory is around RMB 450 (the price may fluctuate due to the exchange rate). The ingredients of the original drug are basically the same as those of the generic drugs. For specific prices and drug details, please consult the medical consultant of Yaode.