How many years should you take Sorafenib for the longest time?

The duration of use of Sorafenib (Sorafenib) can vary based on individual circumstances and the purpose of treatment. In the treatment of renal cell carcinoma and hepatocellular carcinoma, sorafenib is often used as part of long-term maintenance therapy. If sorafenib is effective and tolerated by the patient, treatment may continue for several years, and the treatment plan may be adjusted based on disease progression, side effects, and other factors.

Sorafenib has always been the global gold standard first-line systemic treatment drug for advanced hepatocellular carcinoma (HCC). Two large-scale randomized controlled trials have proven that despite a low radiation response rate, sorafenib is still superior to placebo. The Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) trial demonstrated an improvement in median overall survival (mOS) (from 7.9 months in the placebo group to 10.7 months in the sorafenib group) in hepatocellular carcinoma and renal cell carcinoma, where skin toxicity was the predominant To occur earlier (2-4 weeks after treatment initiation), with their prevalence declining after 6-8 weeks and fewer cases reported after 3 months, improved management of these dermatological side effects could translate into longer treatment times, higher doses, and thus better outcomes.

The original drug of sorafenib has been launched in China and has entered the scope of medical insurance. Different regions have different reimbursement ratios, and the price after reimbursement may vary. SpecificationsThe price of 0.2g*60 tablets may be around 1,200 yuan. The original drug of sorafenib has also been launched overseas, and there are also generic drugs of sorafenib produced in other countries. The price of 0.2g*60 tablets produced by a Bangladesh pharmaceutical factory is around RMB 450 (the price may fluctuate due to the exchange rate). The ingredients of the original drug are basically the same as those of the generic drugs. For specific prices and drug details, please consult the medical consultant of Yaode.