Which generation of targeted drug is Cabozantinib?

Cabozantinib (Cabozantinib) is a second-generation targeted drug. Targeted drugs refer to drugs that interfere with specific molecules or pathways in tumor cells. Targeted drugs can be divided into different generations based on their development history and mechanism of action. Here is a brief introduction to several generations of targeted drugs:

1.First-generation targeted drugs: The first-generation targeted drugs appeared earlier, and they are mainly single-target inhibitors. Early targeted drugs include imatinib (Imatinib, commercial name Gleevec) for the treatment of chronic myeloid leukemia (Chronic Myeloid Leukemia, CML) and erlotinib (Erlotinib, trade name Tarceva) for the treatment of non-small cell lung cancer (Non-Small Cell Lung Cancer, NSCLC), etc.

2.Second generation targeted drugs: The second generation targeted drugs are more selective and specific than the first generation. They usually inhibit multiple related targets at the same time to achieve better efficacy. Cabozantinib (Cabozantinib) is a second-generation targeted drug that can inhibit multiple tyrosine kinases at the same time and has shown good results in the treatment of certain cancers.

3.Third generation targeted drugs: The third generation targeted drugs are further developed on the basis of the second generation and usually have higher affinity and selectivity. These drugs continue to emerge in clinical trials and development, aiming to improve efficacy and reduce drug resistance and side effects.

Please note that the classification of targeted drugs may be relative, as some drugs may have multiple targeting properties, and new drugs are constantly emerging, which may affect the classification of drugs. Therefore, in practice, doctors will choose the most suitable treatment option for their patients based on the latest research and guidelines.

Cabozantinib is not yet available in China and is not included in medical insurance, so it needs to be purchased through overseas channels. There are original drugs abroad, which cost around 35,000~46,000 yuan. Foreign generic drugs are mainly Laos generic drugs and Bangladeshi generic drugs, with prices ranging from The price is around 1,300~2,700 yuan, which is much cheaper than the original drug. It is more suitable for the needs of patients in ordinary families, and the ingredients of the original drug and generic drugs are basically the same.