Cabozantinib efficacy and effects

Cabozantinib (Cabozantinib) is a multi-target tyrosine kinase inhibitor. As a targeted drug, its main function is to inhibit the activity of multiple receptor kinases at the same time, interfering with tumor growth, angiogenesis and metastasis, thereby exerting anti-tumor effects. The efficacy and role of cabozantinib will be introduced in detail below:

1.Inhibit tumor cell proliferation: Cabozantinib can inhibit the activity of multiple receptor kinases, including vascular endothelial growth factor receptor (VEGFR), hepatocyte growth factor receptor (MET), platelet-derived growth factor receptor (PDGFR), etc. These receptor kinases play important roles in the proliferation of tumor cells. By inhibiting the activity of these receptor kinases, cabozantinib can block signaling pathways, inhibit the proliferation and growth of tumor cells, and thereby slow down tumor progression.

2.Inhibit tumor angiogenesis: Tumor growth requires a large blood supply to provide oxygen and nutrients. Vascular endothelial growth factor receptor (VEGFR) is a key regulator of tumor angiogenesis. Cabozantinib inhibits the activity of VEGFR and reduces the signaling pathway of tumor angiogenesis factors (VEGF), thereby blocking the tumor's dependence on blood supply, reducing the tumor's nutrient supply, and inhibiting tumor growth.

3.Inhibition of tumor metastasis: Cabozantinib also inhibits the migration and invasion of tumor cells. METReceptor kinase is involved in regulating cell migration and invasion. Abnormally activated MET is closely related to tumor metastasis and invasion. Cabozantinib can reduce the metastasis ability of tumor cells and block the spread of tumors by inhibiting the activity of MET receptor kinases.

4.Treatment of renal cell carcinoma (RCC): Cabozantinib is one of the first-line treatments for renal cell carcinoma. In patients with advanced or metastatic renal cell carcinoma, cabozantinib can significantly extend the patient's survival and improve their quality of life by inhibiting tumor cell proliferation, angiogenesis and metastasis.

5.Treatment of thyroid cancer (Thyroid Cancer): Cabozantinib is also used to treat some people with thyroid cancer. Cabozantinib may provide an effective treatment option for patients with locally advanced or metastatic thyroid cancer that is refractory to radioactive iodine therapy.

6.Treatment of hepatocellular carcinoma (HCC): Cabozantinib is also used to treat hepatocellular carcinoma. Cabozantinib has also shown some efficacy in patients with hepatocellular carcinoma who have relapsed or progressed after prior treatment with sorafenib.

7.Improving survival and quality of life: Cabozantinib shows broad therapeutic potential in many cancer types due to its inhibitory effects on multiple receptor kinases. In some patients, cabozantinib can extend survival and improve quality of life, allowing patients to better cope with the challenges of cancer.

Although cabozantinib has shown good efficacy in treating some cancers, it can also cause a range of side effects and adverse reactions. Therefore, when using cabozantinib treatment, patients should strictly follow the doctor's prescriptions and recommendations, and receive regular monitoring and follow-up from the doctor to ensure the safety and effectiveness of the treatment. At the same time, if any new discomfort or side effects occur, please report it to your doctor promptly.

Cabozantinib is not yet available in China and is not included in medical insurance, so it needs to be purchased through overseas channels. There are original drugs abroad, which cost around 35,000~46,000 yuan. Foreign generic drugs are mainly Lao generic drugs and Bangladeshi generic drugs, with prices ranging from 1,300 to 2,700 yuan. The price is much cheaper than original drugs and is more suitable for the needs of patients in ordinary families. The ingredients of original drugs and generic drugs are basically the same.