What are the side effects of Cabozantinib?

Cabozantinib (Cabozantinib), as a multi-target tyrosine kinase inhibitor, has significant therapeutic effects on some cancers, but it may also cause a series of side effects and adverse reactions. The following are common side effects of cabozantinib, but please note that each patient may react differently and it is recommended to follow your doctor's advice and monitoring when using the drug:

1. Hypertension: Cabozantinib may cause hypertension due to inhibition of the vascular endothelial growth factor receptor (VEGFR). High blood pressure may need to be controlled with medication or other measures.

2. Diarrhea: Treatment with cabozantinib may cause diarrhea, a common side effect. Patients may need to watch their diet and fluid intake while taking antidiarrheal medications as recommended by their doctor.

3. Fatigue: Patients taking cabozantinib may experience fatigue and weakness. During treatment, patients should get adequate rest and avoid overexertion.

4. Hand-foot syndrome: Cabozantinib may cause redness, swelling, pain, and peeling of the palms and soles of the feet, which is called hand-foot syndrome. Patients may need to keep their hands and feet clean and moisturized, and use topical medications as recommended by their doctor.

5. Nausea and Vomiting: Cabozantinib may cause patients to experience nausea and vomiting. During treatment, patients should avoid spicy and greasy foods and eat in moderation.

6. Loss of appetite: Patients taking cabozantinib may experience symptoms of loss of appetite. During the treatment period, patients should adjust their diet according to the doctor's recommendations to ensure nutritional intake.

7. Proteinuria: Cabozantinib may cause patients to develop symptoms of proteinuria, which is caused by impaired kidney function. Patients may need regular urine tests to monitor kidney function.

8. Thyroid dysfunction: Cabozantinib treatment may affect thyroid function, leading to thyroid dysfunction. Patients may need to undergo thyroid function tests and be treated accordingly based on their doctor's recommendations.

9. Color changes in fingers and toes: Cabozantinib may cause color changes in the fingers and toes, such as becoming pale or purple. This may be caused by reduced blood flow, and patients should keep warm and avoid cold.

10. Abnormal coagulation function: Cabozantinib treatment may affect coagulation function, leading to easy bleeding or prolonged coagulation time. Patients may need blood coagulation tests and avoid strenuous exercise or injury during treatment.

Although cabozantinib may cause the side effects listed above, please note that not all patients will experience these side effects and the degree of side effects may vary from person to person. While using cabozantinib, patients should pay close attention to their symptoms and promptly report any new discomfort or adverse reactions to their doctor. During treatment with cabozantinib, patients need to maintain close communication and monitoring with their doctors. Doctors may adjust doses or give other supportive treatments based on patient response and tolerance to minimize side effects and ensure treatment is effective.

Cabozantinib is not currently on the market in China, and therefore is not included in medical insurance. Therefore, patients cannot purchase it domestically and need to purchase it through overseas channels. There are original and generic drugs of cabozantinib abroad. The original drugs are mainly Japanese original drugs, Turkish original drugs and European version of original drugs. Foreign generic drugs are mainly Laos generic drugs and Bangladeshi generic drugs, with prices ranging from 1,300 to 2,700 yuan, and the ingredients of original drugs and generic drugs are basically the same.