How long does it take for Sofosbuvir and Velpatasvir (Epclusa) to take effect?

Sofosbuvir and velpatasvir (Epclusa) combination needs to be taken according to the doctor's instructions, with or without food, usually once a day. Dosage for children is based on age and weight. Drugs work best when their concentration in the body is maintained at a stable level. Therefore, patients should take sofosbuvir and velpatasvir combination regularly at evenly spaced intervals, and patients should take their medication at the same time every day. Even if symptoms disappear after a period of use, continue taking it for the full prescribed time. Premature discontinuation of sofosbuvir-velpatasvir combination may result in recurrence of hepatitis virus.

Antacids can reduce the absorption of velpatasvir, and other acid-reducing agents used to treat indigestion, heartburn, or ulcers (such as prescription or over-the-counter drugs, including famotidine, omeprazole) may inhibit its effect. If the patient is taking antacids, take them at least 4 hours before or after taking sofosbuvir and velpatasvir combination. Chronic hepatitis C is a disease that can leave serious sequelae on the liver, such as cirrhosis or liver cancer, if left untreated. Therefore, patients need antiviral drugs to support the body and help the liver recover.

The original drug of sofosbuvir and velpatasvir has been launched in China and has entered the scope of Class B medical insurance. The domestic trade name is protonsa, and the specification (400mg+100mg)*28 tablets is priced at about 4,000 yuan per box. The original drug of sofosbuvir and velpatasvir has also been launched overseas. There are also generic drugs of sofosbuvir and velpatasvir produced in other countries. The price of the specification (400mg + 100mg) * 28 tablets produced by Everest Pharmaceutical Factory in Bangladesh is about 850 yuan per box (the price may fluctuate due to the exchange rate). The generic drugs produced abroad are basically the same as the original drugs at home and abroad.