Sirolimus effects and side effects

Sirolimus (sirolimus) is indicated for the prevention of organ rejection in patients over 13 years of age who have received kidney transplants. For patients with low to moderate immune risk, it is recommended that rapamycin be used first in a combination regimen of cyclosporine and corticosteroids, with cyclosporine discontinued 2-months after transplantation; patients with high immune risk (defined as black recipients and/or immunogenic In repeat renal transplant recipients who have lost a previous allograft and/or in patients with high herd-reactive antibodies [peak PRA levels >80%]), the use of rapamycin in combination with cyclosporine and corticosteroids is recommended during the first year after transplantation. Also indicated for the treatment of patients with lymphangioleiomyomatosis (LAM).

The most common side effects of sirolimus are infection, fever, slow wound healing, low counts of various blood cells, blood tests showing altered levels of various substances(including low potassium and low phosphate; elevated fat, cholesterol, glucose, and markers of tissue breakdown and liver and kidney function), diabetes, lymphoceles, pain in various parts of the body, rapid heartbeat, elevated blood pressure, problems affecting the intestines, proteinuria, menstrual irregularities, edema, rashes, and acne.

SirolimusThe original drug has been launched in China and has entered the scope of Class B medical insurance. SpecificationsThe price of each box of 1mg*10 tablets is about 400 yuan. The domestic drug is only available to patients with anti-rejection reactions in organ transplantation. Patients who do not meet the conditions may not be able to purchase this drug. The original sirolimus drug has also been launched overseas. The price of the Turkish version of Specifications1mg*100 tablets per box is around RMB 2,000 (the price may fluctuate due to exchange rates). The ingredients of the original drugs marketed in China are basically the same as those of foreign original drugs. Currently, there are no generic sirolimus drugs produced in other countries.