What should I do if I become resistant to sirolimus?

Sirolimus (sirolimus) is indicated for the prevention of organ rejection after renal transplantation, alone or in combination with calcineurin inhibitors or corticosteroids. It is also approved to treat lymphangioleiomyomatosis. Sirolimus is not approved for liver or lung transplantation, but is used to prevent rejection after failure of other forms of organ transplantation or intolerance to tacrolimus.

Sirolimus is available as 0.5, 1 and 2 mg tablets and as a 1 mg/ml oral solution under the brand name Rapamin. After a loading dose, the usual maintenance dose for adults is 2 mg (1 mg/m2) once daily. Sirolimus is less nephrotoxic than calcineurin inhibitors. Common side effects of sirolimus include anxiety, weakness, depression, dizziness, headache, gastrointestinal upset, mouth ulcers, edema, bone marrow suppression, and rash. Rare but potentially serious adverse events include hyperlipidemia, renal dysfunction, serious and opportunistic infections, embryo-fetal toxicity, infertility, and allergic reactions. Everyone’s constitution is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

SirolimusThe original drug has been launched in China and has entered the scope of Class B medical insurance. SpecificationsThe price of each box of 1mg*10 tablets is about 400 yuan. The domestic drug is only available to patients with anti-rejection reactions in organ transplantation. Patients who do not meet the conditions may not be able to purchase this drug. The original sirolimus drug has also been launched overseas. The price of the Turkish version of Specifications1mg*100 tablets per box is around RMB 2,000 (the price may fluctuate due to exchange rates). The ingredients of the original drugs marketed in China are basically the same as those of foreign original drugs. Currently, there are no generic sirolimus drugs produced in other countries.