Ceritinib/Ceritinib Chinese instructions

1. Indications:Ceritinib/Ceritinib (Ceritinib) is a target It is a therapeutic drug suitable for patients with specific types of non-small cell lung cancer (NSCLC), namely patients with ALK (tyrosine kinase) fusion positive. ALK Fusion positivity is a specific genetic mutation that causes the ALK gene in cancer cells to fuse with other genes, thereby promoting tumor growth and spread. Ceritinib/Ceritinib blocks the proliferation and spread of cancer cells by inhibiting the activity of this abnormal ALK fusion protein, thereby inhibiting the development of tumors.

2. Mechanism of action and pharmacology:Ceritinib/Ceritinib is a tyrosine kinase inhibitor, and its mechanism of action mainly targets ALK fusion protein. In ALK fusion-positive tumor cells, due to gene fusion, the ALK protein is abnormally active, leading to uncontrolled proliferation and differentiation of cancer cells. Ceritinib/Ceritinib can bind to this abnormal ALK fusion protein, thereby inhibiting its activity, blocking cell signaling pathways, inhibiting the proliferation and spread of cancer cells, thereby inhibiting tumor growth.

3. Dosage and usage:Ceritinib/Ceritinib is an oral drug, usually taken after meals. Doctors will individualize the dosage regimen based on the patient's weight, physical condition and type of cancer. The usual starting dose is 450 mg once daily. However, dosage may vary due to individual differences. Patients should strictly follow the doctor's recommendations, take the medicine at a fixed time every day, and do not change the dosage or stop taking the medicine at will.

4. Side effects:Ceritinib/Ceritinib Some side effects may occur during use. Common minor adverse reactions include nausea, vomiting, diarrhea, fatigue, malaise, and decreased appetite. These reactions usually occur early in treatment and may lessen over time. In addition, symptoms such as nasal congestion and runny nose may also occur. Serious adverse reactions may include lung problems such as pneumonia and pulmonary fibrosis, arrhythmias, high blood sugar, high cholesterol and vision problems.

5. Warnings and precautions:

1.Lung problems: If patients develop shortness of breath, cough, chest pain, or other respiratory problems while taking ceritinib/ceritinib, they should seek medical attention immediately. Lung function may need to be monitored and appropriate measures taken.

2.Arrhythmias: Ceritinib/Ceritinib may cause arrhythmias, including QT interval prolongation. During treatment, patients should receive regular EKG monitoring to ensure heart health.

3.High blood sugar and high cholesterol: High blood sugar and high cholesterol may occur while using ceritinib/ceritinib. Patients should check their blood sugar and cholesterol levels regularly and take steps to manage them.

4.Vision problems: Ceritinib/Ceritinib may cause vision problems during use. If vision problems occur, seek medical attention promptly.

6. Contraindications:

Ceritinib/Ceritinib is contraindicated in patients who are allergic to this drug or its ingredients.

7. Drug interactions: During the use of ceritinib/ceritinib, patients should inform their doctors about other drugs they are taking, including prescription drugs, over-the-counter drugs and supplements. Certain drugs may interact with ceritinib/ceritinibInteractions may occur, affecting its efficacy or increasing the risk of adverse reactions. Therefore, doctors need to know all of the medications a patient is taking to determine if treatment needs to be adjusted.

8. Medication for special groups:

1.Pregnant and lactating women:Ceritinib/Ceritinib may be harmful to the fetus and is not recommended for pregnant women. Breastfeeding women should stop breastfeeding during use.

2.Elderly patients: Elderly patients may be more likely to experience side effects when using ceritinib/ceritinib, and doctors may adjust the dose or monitor more frequently.

3.Children and Adolescents:Ceritinib/The safety and effectiveness of Ceritinib have not been established in children and adolescents under 18 years of age and its use is not recommended.

9. Listing and price situation: Ceritinib is currently on the market in China and has been included in medical insurance. Patients can purchase it domestically. Although ceritinib/ceritinib has been included in medical insurance, the price is still very high. The domestic price ranges from about 12,600 to 24,000. The price varies with different specifications. Please consult your local pharmacy for details. Foreign original drugs are divided into original drugs and generic drugs. Foreign original drugs are mainly Swiss Novartis original drugs. The specification is 150mg*150 and the price is about 13,500 yuan. Generic drugs mainly include Bangladeshi version, with specifications of 150mg*30 and the price is around 1,300 yuan. The ingredients of original drugs and generic drugs are basically the same.

Overall, ceritinib/Ceritinib is an important targeted therapy drug that has significant efficacy in patients with ALK fusion-positive non-small cell lung cancer. However, some side effects and discomfort may occur during use, so it is crucial to work closely with your doctor, promptly report symptoms, conduct regular review and monitoring, and follow your doctor's recommendations. Through rational use of medications, patients can expect better treatment effects, improved quality of life, and better prognosis.