How long does it take to become resistant to Ceritinib?

Ceritinib/Ceritinib (Ceritinib) treatment resistance is a complex problem, which is affected by many factors, including genetic variation of tumor cells, treatment regimens, individual differences in patients, etc. Therefore, it is impossible to give an accurate time range for resistance, and each patient's situation may be different.

For patients who use ceritinib/ceritinibALK (tyrosine kinase) fusion-positive non-small cell lung cancer (NSCLC), they may be very sensitive to the drug at first, and their tumors can be effectively controlled and their symptoms improved. However, as treatment progresses, some patients may gradually develop drug resistance, that is, the tumor's response to ceritinib/ceritinib weakens and the therapeutic effect decreases.

In research, it was found that about30%to40% ofALK fusion positiveNSCLCPatients will develop drug resistance after one year of taking ceritinib/ceritinib. This drug resistance may be caused by intracellular ALK mutations, or may be related to the activation of other pathways. Of course, this ratio is for reference only, and the actual resistance rate will vary depending on factors such as individual patient differences, genetic variations, and treatment strategies.

For patients who develop drug resistance, it is usually necessary to consider changing treatment options clinically. New generations of ALK inhibitors and other targeted drugs continue to be developed in clinical trials, providing new treatment options for drug-resistant patients. These new drugs may have different inhibitory effects on drug-resistant cells and bring better therapeutic effects.

Ceritinib/Ceritinib has been launched in China and has been included in medical insurance. Patients can purchase it domestically, but the price is high. Please consult your local pharmacy for details. Foreign original drugs are divided into original drugs and generic drugs. Foreign original drugs are mainly Swiss Novartis original drugs. Specification150mg*150The price is about13500 About 13500 yuan. Generic drugs mainly include Bangladeshi version, with specifications of 150mg*30 and the price is around 1,300 yuan. The ingredients of original drugs and generic drugs are basically the same.