Ceritinib/Ceritinib vs. Crizotinib? Which one is better?

Ceritinib/Ceritinib (Ceritinib) and crizotinib (Crizotin ib) are targeted drugs for ALK (tyrosine kinase) fusion-positive non-small cell lung cancer (NSCLC). They are second-generation ALK inhibitors used to treat patients with ALK fusion-positive NSCLC. Although they have similar goals, they have some differences in some aspects. Here is their comparison:

1.Drug efficacy: Ceritinib/Ceritinib and crizotinib have shown significant efficacy in the treatment of ALKfusion-positive NSCLC patients. In clinical trials, both drugs prolonged progression-free survival (PFS) and overall survival (OS). However, their efficacy may vary in different patients, depending on individual patient differences and tumor characteristics.

2.Drug resistance: Drug resistance is a problem that needs attention, whether it is ceritinib/ceritinib or crizotinib. In the process of using these drugs, some patients may gradually develop drug resistance, that is, the tumor's response to the drug weakens, leading to disease progression. Drug resistance is a complex biological process involving multiple molecular mechanisms. Management of resistance may require switching to a newer generation of ALK inhibitors or other treatment strategies.

3.Side effects and safety:Ceritinib/CeritinibThere are some differences in side effects and safety with crizotinib. Their common adverse reactions include nausea, vomiting, diarrhea, fatigue, etc. However, the specific manifestations and severity of side effects may vary among individual patients. During the period of medication, patients need to pay close attention to their physical condition and promptly report any new symptoms or discomfort to their doctor. Based on the patient's response and adverse reactions, the doctor may adjust the dose or take other measures to manage the adverse reactions to ensure the safety and effectiveness of the treatment.

4.Usage and dosage:Ceritinib/Ceritinib and crizotinib also have some differences in usage and dosage. Ceritinib/Ceritinib is an oral capsule, 450mg taken once daily, usually within 1 hour after a meal. Crizotinib is also an oral medication available at a dose of 250 mg daily, usually after a meal. With both medications, it is important to take your medication on time to ensure stable drug levels and optimal treatment effects.

In general, ceritinib/ceritinib and crizotinib are effective treatments for ALKfusion-positive NSCLC. Which drug to choose depends on factors such as the patient's specific situation, risk of resistance, and tolerability. For different patients, doctors will develop the best treatment plan based on individual differences and treatment needs. Therefore, patients should work closely with their doctors and follow their recommendations to obtain the best possible treatment results.

Ceritinib/Ceritinib has been launched in China and has been included in medical insurance. Patients can purchase it domestically, but the price is high. Please consult your local pharmacy for details. Foreign original drugs are divided into original drugs and generic drugs. Foreign original drugs are mainly Swiss Novartis original drugs. Specification150mg*150The price is about13,500 yuan. Generic drugs mainly include Bangladeshi version, with specifications of 150mg*30 and the price is around 1,300 yuan. The ingredients of original drugs and generic drugs are basically the same.