How much does a box of Crizotinib cost?

Crizotinib (Crizotinib) is an oral, small molecule targeted drug commonly used to treat certain types of cancer, especially non-small cell lung cancer (NSCLC) and certain neuroblastomas. The drug can inhibit some fusion protein kinases, such as ALK (Anaplastic Lymphoma Kinase) and ROS1 (c-ros oncogene 1), which play important cancer-promoting roles in some cancers.

Crizotinib is currently on the market in China and is included in medical insurance. Patients can purchase it domestically, and the price is around 6,000~12,000 yuan. Since the price of medical insurance policies varies greatly across regions, please consult your local pharmacy or medical insurance bureau for specific prices. There are original and generic versions of crizotinib available abroad. The original version is mainly Pfizer’s original drug, and the price is around 11,000 yuan. Generic drugs are mainly from Bangladesh and Laos. Due to different pharmaceutical manufacturers and drug specifications, generic drugs cost around 2,700~3,000 yuan. Moreover, the ingredients of foreign original drugs and generic drugs are basically the same as those of domestic drugs.

Crizotinib is mainly used to treat patients with advanced non-small cell lung cancer (NSCLC) who have been confirmed to have the ALK fusion gene, and patients with advanced NSCLC who have the ROS1 fusion gene. In addition, the drug may also be suitable for other cancer types, but this is currently under investigation.

Crizotinib is a tyrosine kinase inhibitor that can prevent the growth and spread of tumor cells by inhibiting the activity of fusion protein kinases.

Crizotinib may cause some side effects, including nausea, vomiting, diarrhea, fatigue, and visual impairment. Different patients may have different tolerances and reactions to the drug, so close monitoring and consultation with a physician should be performed during treatment.

Crizotinib is an individualized treatment because it targets specific genetic variations. Before choosing this drug for treatment, genetic testing of the patient's tumor is usually required to confirm whetherALK or ROS1 fusion gene and other mutations.