Chinese instructions for Crizotinib

1. Indications: Crizotinib is a tyrosine kinase inhibitor suitable for the treatment of specific types of malignant tumors. Main indications include:

1.Positive epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC): used to treat carriers patients with late-stage NSCLC with span>ALK fusion gene or ROS1 rearrangement.

2.Musculoskeletal sarcoma (IMT): For the treatment of adult patients with local progression, local recurrence, or distant metastasis of kinase-rich lesions (KDR, PDGFRA, PDGFRB).

2. Mechanism of action and pharmacology: Crizotinib is a tyrosine kinase inhibitor that inhibits the proliferation and survival of cancer cells by inhibiting the tyrosine kinase activity of ALK fusion protein and ROS1 fusion protein. In addition, crizotinib can also inhibit receptor tyrosine kinases such as KDR, PDGFRα, and PDGFRβ, thereby inhibiting tumor angiogenesis.

3. Dosage and usage: ALK or ROS1 fusion gene should be tested before treatment to ensure that the patient is suitable for crizotinib treatment. Doses are as follows:

1.Non-small cell lung cancer (NSCLC): Take 250mg orally daily, continuously. It is recommended to take it after meals.

2.Musculoskeletal sarcoma (IMT): Take 300mg orally daily for continuous use. It is recommended to take it after meals.

4. Side effects: Treatment with crizotinib may cause the following side effects:

1.The most common side effects include fatigue, loss of appetite, nausea, vomiting, diarrhea and constipation.

2.Pneumonia, cough, difficulty breathing, etc. may occur in the respiratory system.

3.Cardiovascular aspects may include QT prolongation, tachycardia, arrhythmia, etc.

4.Abnormal liver function may occur in liver function.

5.Visual impairment may include blurred vision, light sensitivity, dry eyes, etc.

6.Headache, dizziness, insomnia, etc. may occur in the nervous system.

5. Warnings and Precautions: Before using crizotinib, doctors should conduct a detailed assessment of the patient to understand their medical history and current health status. Please pay attention to the following matters during use:

1.Electrocardiogram monitoring: ECG monitoring should be performed before the start of treatment and regularly during treatment, especially for patients with a history of cardiovascular disease.

2.Liver function monitoring: Liver function needs to be monitored regularly during treatment. Once abnormalities occur, the treatment plan should be adjusted in a timely manner.

3.Visual vision monitoring: Regular vision examinations should be performed during treatment. If vision abnormalities occur, seek medical attention promptly.

4.Contraindicated during pregnancy: Crizotinib is contraindicated in pregnant and lactating women, and effective contraceptive measures must be taken during treatment.

6. Contraindications: Crizotinib is contraindicated in the following circumstances:

1.Patients who are allergic to crizotinib or any ingredient in this medicine.

2.Pregnant and lactating women.

7. Drug interactions: When using crizotinib, it is necessary to avoid using it with the following drugs at the same time, because it may affect the efficacy or increase the occurrence of side effects:

1.StrongCYP3A inhibitors: such as ketoconazole, itraconazole, etc., may increase the plasma concentration of crizotinib.

2.StrongCYP3A inducers: such as ribavirin, carbamazepine, etc., may reduce the plasma concentration of crizotinib.

3.Gastric acid inhibitors: such as omeprazole, rabeprazole, etc., may reduce the absorption of crizotinib.

8. Medication for special groups: For elderly patients, patients with impaired liver and kidney function, and children, careful consideration should be given to the use of crizotinib, and the dose should be adjusted under the guidance of a doctor.

9. Listing and price situation: Crizotinib is currently on the market in China and is included in medical insurance. Patients can purchase it domestically at a price of around 6,000~12,000 yuan. Since the price of medical insurance policies varies greatly across regions, please consult your local pharmacy or medical insurance bureau for specific prices. There are original and generic versions of crizotinib available abroad. The original version is mainly Pfizer’s original drug, and the price is around 11,000 yuan. Generic drugs are mainly from Bangladesh and Laos. Due to different pharmaceutical manufacturers and drug specifications, generic drugs cost around 2,700~3,000 yuan. Moreover, the ingredients of foreign original drugs and generic drugs are basically the same as those of domestic drugs.

Crizotinib is a tyrosine kinase inhibitor mainly used to treat non-small cell lung cancer with ALK fusion gene and ROS1 rearrangement as well as musculoskeletal sarcoma with kinase-rich lesions. When using this drug, attention should be paid to the monitoring of the patient's electrocardiogram, liver function, and vision, as well as dosage adjustments for special groups such as elderly patients, patients with impaired liver and kidney function, and children.