Which company develops and produces Crizotinib?

Crizotinib (Crizotinib) was originally developed and produced by Pfizer (Pfizer). Pfizer is a global pharmaceutical company founded in 1849 and headquartered in New York City, United States. Pfizer is one of the world's largest pharmaceutical companies, developing and manufacturing a wide range of medicines, including those used to treat cancer, cardiovascular disease, infectious diseases and other diseases. Crizotinib (Crizotinib) is a product of Pfizer under the brand name Xalkori®, which is used to treat specific types of non-small cell lung cancer (NSCLC).

Crizotinib (Crizotinib) was developed based on in-depth research on the molecular biology and genetics of cancer. Scientists have discovered an abnormality in a fusion gene called ALK (Anaplastic Lymphoma Kinase) in some patients with non-small cell lung cancer (NSCLC). This genetic abnormality causes the ALK protein to fuse with other proteins, thereby activating abnormal signaling pathways and promoting the growth and spread of tumor cells.

Pfizer's research team gained an in-depth understanding of the molecular characteristics of this ALK fusion gene and conducted drug screening, and finally discovered crizotinib, a targeted therapeutic drug targeting the ALK fusion protein.

In 2011, crizotinib (Crizotinib), as a revolutionary therapeutic drug, received emergency approval from the U.S. Food and Drug Administration (FDA) for the treatment of localized late-stage disease. stage or metastatic ALKpositiveNSCLCpatients, and ROS1fusion-positiveNSCLCpatient. Subsequently, this drug was approved by many countries around the world and became one of the important treatment options for patients with certain lung cancers.

Crizotinib is currently on the market in China and is included in medical insurance. Patients can purchase it domestically. The price is around 6,000~12,000 yuan. Since the price of medical insurance policies varies greatly in various places, please consult the local pharmacy or medical insurance bureau for specific prices. There are original and generic versions of crizotinib available abroad. The original version is mainly Pfizer’s original drug, and the price is around 11,000 yuan. Generic drugs are mainly from Bangladesh and Laos. Due to different pharmaceutical manufacturers and drug specifications, generic drugs cost around 2,700~3,000 yuan. Moreover, the ingredients of foreign original drugs and generic drugs are basically the same as those of domestic drugs.