What disease does Crizotinib treat?

Crizotinib (Crizotinib) is an oral targeted therapy drug mainly used to treat a specific type of cancer, namely tyrosine kinase fusion-positive non-small cell lung cancer (NSCLC).

Non-small cell lung cancer (NSCLC) is one of the main types of lung cancer, accounting for the majority of all lung cancer cases. It can be further divided into different subtypes, some of which include tumors positive for ALK (Anaplastic Lymphoma Kinase) or ROS1 (c-ros Oncogene 1) fusions.

In some NSCLC patients, tumor cells fuse with the ALK or ROS1 genes, forming abnormal fusion proteins. These fusion proteins activate abnormal signaling pathways, leading to abnormal growth and proliferation of tumor cells, thus promoting the development of cancer. Crizotinib, as a targeted therapy drug, targets these abnormal ALK and ROS1 fusion proteins and inhibits their activity, thereby blocking the growth of tumor cells and slowing down the progression of cancer.

Therefore, crizotinib is mainly used to treat patients with locally advanced or metastatic ALK-positive NSCLC and ROS1fusion-positive NSCLC patients. It has been approved by the U.S. Food and Drug Administration (FDA) and other regulatory agencies and is used globally as an effective treatment option for certain lung cancer patients. However, crizotinib can also cause a range of side effects, so before use, patients should be evaluated and monitored by a physician to ensure safe and effective treatment.

Crizotinib is currently on the market in China and is included in medical insurance. Patients can purchase it domestically at a price of 6000~12000The price is about RMB 10,000. Since the price of medical insurance policies varies greatly in different places, please consult the local pharmacy or medical insurance bureau for specific prices. There are original and generic versions of crizotinib available abroad. The original version is mainly Pfizer’s original drug, and the price is around 11,000 yuan. Generic drugs are mainly from Bangladesh and Laos. Due to different pharmaceutical manufacturers and drug specifications, generic drugs cost around 2,700~3,000 yuan. Moreover, the ingredients of foreign original drugs and generic drugs are basically the same as those of domestic drugs.