What should I do if I become resistant to Sotorasib?

If a patient develops drug resistance after treatment with Sotorasib (Sotorasib), he should communicate with his doctor in time and use the drug as directed. 9% of patients permanently discontinued sotoraxib due to adverse reactions such as hepatotoxicity. Patients can consider other treatment options, such as participation in clinical trials, combination use of targeted therapies, or other new anti-tumor drugs, but these options often require evaluation and discussion under the guidance of a professional team.

In rats, at a clinical dose of 960 mg, nephrotoxicity occurred at doses resulting in exposures approximately 0.5 times the human AUC, including minimal to significant histological tubular degeneration/necrosis and increases in kidney weight, urea nitrogen, creatinine, and urinary biomarkers of tubular injury. Increased cysteine u200bu200bS-conjugated beta-lyase pathway metabolism in rat kidneys may render rats more susceptible to nephrotoxicity than humans due to the local formation of a putative sulfur-containing metabolite.

SotoracibThe original drug has not yet been launched in China, so it is not covered by medical insurance. Domestic patients cannot yet purchase this drug. The price of Hong Kong original research versionsotorasibuSpecifications120mg*240 tablets is about RMB 80,000, and the European original research version 120mg*240 tablets is priced at about RMB 44,040 (the price may fluctuate due to the exchange rate), which is relatively expensive. There are also cheaper generic drugs for sale in other countries. The specifications of the Laos Element Pharmaceutical Factory are 120mg*56 tablets and the price is around 4800 yuan (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of foreign generic drugs are basically the same as the original drugs.