Indications of Defibrotide/Defibrotide

Defibrotide/Defibrotide (Defibrotide) is a drug mainly used to treat specific types of blood diseases. Its main indication is hepatic veno-occlusive disease (sinusoidal obstruction syndrome, SOS) or hepatic veno-occlusive disease (veno-occlusive disease, VOD). These conditions are complications associated with treatments such as hematopoietic stem cell transplantation (bone marrow transplant or stem cell transplant) and can be life-threatening.

Hepatic veno-occlusive disease (SOS/VOD) is a rare but serious hepatic vascular disease. Its pathogenesis involves damage to capillary endothelial cells, inflammation, and accumulation of fibrin in small blood vessels. This may lead to liver congestion and liver cell damage, thereby affecting liver function. In severe cases, it may also lead to multiple organ dysfunction. SOS/VODOften associated with hematopoietic stem cell transplants such as bone marrow transplants or stem cell transplants, especially after high-dose chemotherapy.

Defibrotide/Defibrotide SodiumAs a special drug, it has been widely studied and used for the treatment of SOS/VOD. It is thought to positively influence the pathophysiological processes of disease through multiple pathways. Defibrinoside/Defibrotide sodium can reduce the inflammation and damage of capillary endothelial cells and promote the fibrinolysis process, thus helping to restore the normal function of blood circulation. This mechanism is important in alleviating liver problems and other related complications caused by SOS/VOD.

Defibrinoside/Defibrotide SodiumIt is not currently on the market in China, let alone covered by medical insurance, so patients cannot purchase it domestically and need to purchase it through foreign purchasing channelsDefibrotide Sodium/Defibrotide Sodium. OverseasDefibrotide/Defibrotide SodiumThere are only original drugs and no generic drugs. The cheaper original drug is the Turkish original drug, which costs about21,000The price is still very high, around RMB 10,000.