Are there generic versions of Defibrotide/Defibrotide?

Hepatic veno-occlusive disease (SOS/VOD) is a severe liver vascular disease that is often associated with treatment modalities such as hematopoietic stem cell transplantation (bone marrow transplantation or stem cell transplantation). During these treatments, capillary endothelial cell damage, inflammation, and fibrin accumulation in small blood vessels may lead to liver congestion and damage, and even multi-organ dysfunction.

Defibrotide/Defibrotide SodiumAs a mixture, it improves the pathophysiological process of SOS/VOD through various ways. It reduces inflammation and damage to capillary endothelial cells and promotes the fibrinolytic process, thus helping to restore normal blood circulation. Clinical studies have shown that Defibrotide/Defibrotide Sodium treatment can significantly reduce the 28 day mortality of SOS/VOD patients, reduce the severity of the disease, and improve the survival rate.

Defibrinoside/Defibrotide Sodium is not currently on the market in China, so patients cannot purchase it domestically and need to purchase it through foreign purchasing channelsDefibrotide/Defibrotide Sodium. OverseasDefibrinoside/Defibrotide Sodium only has original drugs and no generic drugs. The cheaper original drugs are Turkish original drugs, which cost about 21,000 yuan, which is still very high.

In clinical practice, Defibrotide/Defibrotide Sodium is usually administered in the form of injection, and the dosage and course of treatment will be adjusted according to the patient's condition. The formulation of treatment plans requires doctors to consider comprehensive factors such as the patient's age, weight, and severity of illness. During the period when patients are taking Defibrotide/Defibrotide Sodium , doctors will closely monitor their condition and reactions to ensure the safety and effectiveness of the drug.

AlthoughDefibrotide/Defibrotide Sodium is in the treatment ofSOS/VODIt has shown certain efficacy, but it still needs to be used with caution. Medications may cause some side effects, such as bleeding tendencies, nausea, headaches, etc. Therefore, patients need to pay close attention to their physical condition during medication and communicate with their doctors at any time. Under the guidance of a doctor, the rational use of Defibrinoside/Defibrotide Sodium can help improve the symptoms of SOS/VOD patients, improve their quality of life, and contribute to the success of treatment.