How many boxes of Sotorasib should you take in a month?

Sotorasib, the first KRAS G12c inhibitor to enter the clinic and is currently being studied in the largest clinical program, has demonstrated rapid, deep and durable anti-cancer activity with a positive benefit-risk profile in patients with locally advanced and metastatic non-small cell lung cancer (NSCLC) with KRAS G12C mutations in a once-daily oral formulation. As part of its evaluation for accelerated approval, the FDA requires postmarketing trials to investigate whether lower doses have similar clinical effects.

Lung cancer is the leading cause of cancer-related death worldwide, killing more people worldwide than colon, breast, and prostate cancer combined. The overall survival rate of non-small cell lung cancer is improving, but the survival rate of patients with advanced stage is still very low, and the 5-year survival rate of metastatic patients is only 7%. The recommended dose of sotoraxib after its launch is 960 mg (which can be three 320 mg tablets or eight 120 mg tablets), taken orally once a day until disease progression or unacceptable toxicity occurs. The common specification is 120 mg*240 tablets, so patients may take about one box a month.

SotoracibThe original drug has not yet been launched in China, so it is not covered by medical insurance. Domestic patients cannot yet purchase this drug. The price of Hong Kong original research versionsotorasibuSpecifications120mg*240 tablets is about RMB 80,000, and the European original research version 120mg*240 tablets is priced at about RMB 44,040 (the price may fluctuate due to the exchange rate), which is relatively expensive. There are also cheaper generic drugs for sale in other countries. The specifications of the Laos Element Pharmaceutical Factory are 120mg*56 tablets and the price is around 4800 yuan (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of foreign generic drugs are basically the same as the original drugs.