How long does it take to take Osimertinib?

Osimertinib is an oral, CNS-active third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that selectively inhibits wild-type EGFR in patients with advanced non-small cell lung cancer (NSCLC) with EGFR TKI-activating mutations, including the T790M mutation, which often underlies acquired resistance to early EGFR TKIs. Relative to the first-generation EGFR TKIs (erlotinib or gefitinib) that are the standard of care as first-line treatment for EGFR activating mutation-positive advanced non-small cell lung cancer.

Osimertinib significantly prolonged median progression-free survival (PFS), with separation of the PFS survival curves evident at the first 6-week assessment time point. Across all prespecified groups, osimertinib prolonged PFS compared with standard EGFR TKI therapy, independent of the presence of EGFR mutations at study entry and the presence of CNS metastases at study entry. For the treatment of patients with non-small cell lung cancer (NSCLC) in the adjuvant setting, patients are treated until disease relapse or unacceptable toxicity or for up to 3 years. Patients with metastatic lung cancer are treated until disease progression or toxicity is unacceptable.

OsimertinibThe original drug has been launched in China and has entered the scope of medical insurance. Its name is Osimertinib Mesylate Tablets. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. SpecificationThe price of 80mg*30 tablets per box is around RMB 5,000, which is relatively expensive. The original drug of Osimertinib has also been launched overseas, and there are also generics of Osimertinib produced in other countries. For example, the price of 80mg*30 tablets per box produced by Bangladesh Yaopin International is around RMB 850 (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of the generic Osimertinib and the original drug are basically the same.