Osimertinib has been taken for ten years without resistance

If a patient has been taking Osimertinib for more than ten years and has no resistance, that's very good news. Osimertinib is commonly used to treat non-small cell lung cancer with EGFR (epidermal growth factor receptor) mutations, and some patients may derive long-term benefit from the drug. Specific treatment times and results may vary among individual patients. Everyone responds differently to drugs, so some patients may develop resistance over a shorter period of time.

Osiimertinib exhibits linear pharmacokinetics, with median peak plasma concentrations reached 6 hours after oral administrationWith once-daily dosing, steady-state osimertinib plasma concentrations are reached after 15 days, resulting in a threefold accumulation of the drug. Osimertinib is primarily metabolized by in vitro oxidation (mainly CYP3A4) and dealkylation. At steady state, exposure to these active metabolites is approximately 10% of osimertinib exposure. The primary route of elimination of osimertinib is in the feces (68%), with 14% eliminated in the urine and less than 2% eliminated as unchanged drug. If patients are still not resistant to osimertinib after ten years, that means they are responding well to the drug and the drug is still effective in controlling their tumors. In this case, continued treatment with osimertinib may be appropriate.

OsimertinibThe original drug has been launched in China and has entered the scope of medical insurance. Its name is Osimertinib Mesylate Tablets. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. SpecificationThe price of 80mg*30 tablets per box is around RMB 5,000, which is relatively expensive. The original drug of Osimertinib has also been launched overseas, and there are also generics of Osimertinib produced in other countries. For example, the price of 80mg*30 tablets per box produced by Bangladesh Yaopin International is around RMB 850 (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of the generic Osimertinib and the original drug are basically the same.