What should I do if I am resistant to Osimertinib?

When a patient develops resistance to Osimertinib (Osimertinib) treatment, he or she can follow the doctor’s advice to retest tumor gene mutations, look for other targeted treatment options, or consider chemotherapy or immunotherapy, or participate in clinical trials. Since everyone’s body is different, their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

Resistance may be related tonew mutations in the EGFR gene. By re-testing the genetic mutations of tumor tissues or cells, it is possible to determine whether new mutations have emerged and to adjust treatment plans based on the test results. If osimertinib is no longer effective, other targeted therapies may need to be considered. For example, patients with EGFR gene mutation-positive non-small cell lung cancer may try first- or second-generation EGFR inhibitors, such as gefitinib or erlotinib. In cases of resistance, chemotherapy or immunotherapy may be treatment options. Chemotherapy drugs kill cancer cells directly, while immunotherapy activates the patient's own immune system to attack cancer cells. Participation in clinical trials of novel treatments that target mechanisms of resistance may be an option.

OsimertinibThe original drug has been launched in China and has entered the scope of medical insurance. Its name is Osimertinib Mesylate Tablets. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. SpecificationThe price of 80mg*30 tablets per box is around RMB 5,000, which is relatively expensive. The original drug of Osimertinib has also been launched overseas, and there are also generics of Osimertinib produced in other countries. For example, the price of 80mg*30 tablets per box produced by Bangladesh Yaopin International is around RMB 850 (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of the generic Osimertinib and the original drug are basically the same.