Dolutegravir Sodium Chinese instructions

1. Indications: Dolutegravir Sodium (Dolutegravir Sodium) is suitable for the treatment of human immunodeficiency virus (HIV)-1 infection. It is usually used as part of antiretroviral therapy (ART) in combination with other antiretroviral drugs to reduce viral load, delay disease progression, and improve the patient's immune function.

2. Mechanism of action and pharmacology: Dolutegravir sodium belongs to the integrase inhibitors (INSTIs) class of drugs. By inhibiting the activity of HIV integrase, it prevents the virus from integrating its genetic material into the host cell genome, thereby blocking the replication and spread of HIV. It works in the following ways:

1.Prevent the integration of virusDNA, thereby inhibiting the replication of HIV.

2.Reduce the number of viruses in the body, reduce viral load, and improve immune function.

3. Dosage and usage: The dosage and usage of dolutegravir sodium should be based on the doctor’s advice and prescription. Generally, it is taken orally once a day with a meal or on an empty stomach. If the dosage or usage needs to be adjusted, this should be done under the guidance of a doctor.

4. Side effects: Dolutegravir sodium may cause some side effects, including but not limited to:

1.Headache, fatigue, dizziness and other general discomforts.

2.Gastrointestinal reactions such as nausea, vomiting, and diarrhea.

3.Skin discomfort such as rash and itching.

4.Musculoskeletal symptoms such as muscle pain and joint pain.

5.Abnormal liver function such as elevated liver enzymes.

5. Warnings and Precautions: When using dolutegravir sodium, patients should pay attention to the following:

1.If you have severe allergic reactions, abnormal liver function or other serious adverse reactions, you should seek medical treatment immediately.

2.Long-term use of medications requires regular monitoring of liver function, kidney function and blood tests.

3.Women who are pregnant or planning to become pregnant should consult their doctor to determine whether to continue using this medicine.

4.Communicate with your doctor about drug interactions and avoid adverse reactions caused by simultaneous use with other drugs.

6. Contraindications: Dolutegravir sodium is contraindicated in the following circumstances:

1.Patients with known hypersensitivity to dolutegravir sodium or any component of the drug.

2.Pregnant women in the first three months of pregnancy (should consult a doctor before considering use).

7. Drug interactions: Dolutegravir sodium may interact with other drugs, including but not limited to:

1.Interactions with other antiretroviral drugs, antifungal drugs, antituberculosis drugs, etc.

2.Interactions with over-the-counter drugs, herbal medicines, dietary supplements, etc.

8. Medication for special groups: When using dolutegravir sodium in special groups such as elderly patients, patients with liver and kidney dysfunction, and children, special attention needs to be paid to dosage and monitoring.

9. Availability and price: Dolutegravir sodium has been launched in China, but it has not yet been included in medical insurance. Patients can purchase it in hospital pharmacies at a price of around 1,200 yuan. Please consult the local hospital pharmacy for specific prices. Dolutegravir sodium is cheaper abroad, mainly Indian generic drugs, with a price of around 350 yuan, and the ingredients of domestic original drugs and foreign generic drugs are basically the same.

The above is a basic overview of the Chinese instructions for dolutegravir sodium. Before using this drug, patients should consult their doctor to fully understand the drug's indications, mechanism of action, dosage, side effects and other information to ensure reasonable and safe use of the drug. The doctor will formulate an appropriate treatment plan based on the patient's specific situation and conduct regular monitoring and adjustments.