Will regorafenib be effective if taken for more than 3 years?

Regorafenib(Regorafenib)This oral multikinase inhibitor has been shown to provide a survival benefit for patients with metastatic colorectal cancer (mCRC). The recommended dose is 160 mg/day for 3 weeks followed by 1 week of no treatment. Although most regorafenib-related adverse events (AEs) may resolve within the first 8 weeks of treatment, some may require dose reduction or treatment interruption.

When regorafenib is used to treat some specific types of cancer, such as advanced colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma, the efficacy may vary due to individual differences. For some patients, regorafenib may remain effective for more than 3 years. Each patient's situation is unique, and treatment response may vary based on individual differences. The therapeutic effect of regorafenib is affected by many factors, including tumor type, tumor grade, drug resistance, individual health status, etc.

RegofenibThe original drug has been launched in China and has entered the scope of Class B medical insurance. Reimbursement is limited to patients who meet the indications. SpecificationThe price of each box of 40mg*28 tablets is around RMB 5,000. The reimbursement ratio is different in different regions, and the price after reimbursement is different. The Turkish version of regorafeniboriginal drug specifications 40mg*28 tablets sold overseas is priced around RMB 6,400 per box (the price may fluctuate due to exchange rates). There are also generic regorafenib drugs produced in other countries, and their drug ingredients are basically the same as those of the original drug. The price of a box of 40mg*90 tablets produced by a Bangladesh pharmaceutical factory is around 2,900 yuan (the price may fluctuate due to exchange rates).