What should I do if I become resistant to Rivaroxaban?

If resistance to rivaroxaban (Rivaroxaban) is believed to have developed or reduced efficacy, your doctor may consider adjusting the dose of rivaroxaban or switching to another anticoagulant drug if resistance does exist. Whether adjusting your dose or changing medications, it's important to follow your doctor's instructions and not stop or change the way you use your medications on your own, as this may bring risks and complications.

Patients with minor bleeding are treated conservatively and single-dose anticoagulation is skipped or delayed. Patients with major bleeding receive initial treatment with antifibrinolytic drugs, such as tranexamic acid, orε-Aminocaproic acid is used off-label as a hemostatic agent in NOAC-related major bleeding, but there are currently insufficient efficacy data. For patients with life-threatening bleeding associated with anticoagulation with a direct factor Xa inhibitor, Andexanet alfa or unactivated 4-factor prothrombin complex concentrate (PCC) may be used. Although somePCC products may also contain coagulation inhibitors such as heparin, antithrombin, protein C, protein S, and protein Z to reduce the risk of thrombosis. Oral activated charcoal may also be considered if ingestion occurs within 1 to 2 hours of taking the medication.

RivaroxabanThe original drug is already on the market in China and can be found under Class B medical insurance. SpecificationsThe price of 10mg*5 tablets is around RMB 100. This drug may be sold in domestic pharmacies or hospitals. The Turkish version of rivaroxabanoriginal drug marketed overseas, specifications10mg*10 tablets, is priced around RMB 170 (the price may fluctuate due to exchange rates). The ingredients of the original rivaroxaban drug sold domestically and abroad are basically the same. Currently, there are no generic drugs produced in other countries on the market overseas.