Efavirenz/emtricitabine/tenofovir (EFV+FTC+TDF, Viraday) instructions

Efavirenz/Emtricitabine/Tenofovir (EFV+FTC+TDF, Viraday) is a compound antiretroviral drug that contains efavirenz EFV (EFV), emtricitabine (FTC), and tenofovir (TDF) are used to treat human immunodeficiency virus (HIV) infection.

Indications:

Efavirenz/Emtricitabine/TenofovirApplicable to adult patients and Treatment of HIV-1 infection in adolescents (12 years old and above weighing ≥40kg).

Mechanism of action:

Efavirenz/Emtricitabine/Tenofovir is a highly effective combination antiretroviral therapy. Among them, EFV is a non-nucleoside reverse transcriptase inhibitor (NNRTI), which can inhibit HIV reverse transcriptase, thereby blocking viral replication. FTC and TDF are nucleoside reverse transcriptase inhibitors (NRTI), which inhibit viral replication by interfering with viral reverse transcriptase. These three drugs, used in combination, work synergistically to help slow viral replication, reduce viral load, and maintain the patient's immune function.

Pharmacology:

EFV, FTC and TDF are rapidly absorbed after oral administration. EFVcan be taken with food, but attention should be paid to the taking time to reduce the occurrence of some side effects. FTC and TDF have high bioavailability and can effectively reach target cells.

Dosage and usage:

Adults and adolescents (12 years old and above and weighing ≥40kg): The recommended dose is 1 tablet per day, taken orally.

Side effects:

Efavirenz/Emtricitabine/Tenofovir may cause the following common side effects: headache, fatigue, nausea, vomiting, diarrhea, rash, abnormal liver function, etc. Some patients may develop mental disorders, including depression, anxiety, insomnia, etc. If serious adverse reactions occur during use, please inform your doctor immediately.

Warnings and Precautions:

1.Efavirenz/Emtricitabine/Tenofovir should only be used under the supervision of an experienced HIV physician.

2.Alcohol and drug abuse, as well as tasks requiring high levels of alertness (such as driving), should be avoided while using EFV.

3.Efavirenz/Emtricitabine/Tenofovir is not used to treat HIV-2 infection because its efficacy against HIV-2 has not been confirmed.

4.Patients should have regular liver function tests to monitor liver response and possible side effects.

Contraindications:

1.It is contraindicated in patients who are allergic to any component of efavirenz/emtricitabine/tenofovir.

2.For patients with abnormal liver function or renal function, especially those with impaired renal function, efavirenz/emtricitabine/tenofovir should be used with caution.

Drug interactions:

Severe interactions with other drugs should be avoided when usingefavirenz/emtricitabine/tenofovir. Particular attention should be paid to combined use with other antiretroviral drugs (such as other NNRTIs, NRTIs, PIs, etc.) or drug-metabolizing enzyme inducers and inhibitors.

Medicine for special groups:

1.Children: Not recommended for use by patients younger than12 years old or weighing less than40kg pan>Efavirenz/Emtricitabine/Tenofovir.

2.Pregnant women: It should be used with caution during pregnancy, and the decision whether to use efavirenz should be based on the benefits and risks assessed by the doctor. Efavirenz/Emtricitabine/Tenofovir

3.Lactating period: Not recommended for breastfeeding womenEfavirenz/Emtricitabine/Tenofovir.

Listing and price status:

Efavirenz/Emtricitabine/Tenofovir (EFV+FTC+TDF, Viraday) is not currently on the market in China, so patients cannot purchase it domestically and need to purchase it through overseas purchasing channels. The cheaper ones abroad are mainly Indian generic drugs, which cost around 380 yuan.

The above is forefavirenz/emtricitabine/tenofovir (efavirenz/emtricitabine/tenofovir), patients should consult a professional physician before using the drug and follow the physician's advice and supervision during treatment. At the same time, each patient's situation may be different, so the treatment plan needs to be individualized and worked closely with the doctor to ensure optimal efficacy and safety.