What should I do if I become resistant to Romiplostim?

If a patient is receiving romiplostim for immune thrombocytopenia, which may need to be taken long-term, the doctor will check the patient's body's response to romiplostim during treatment. If platelet levels have not increased enough to prevent bleeding after 4 weeks of taking the maximum dose of romiplostim, the doctor may stop romiplostim treatment, but if the patient is receiving treatment for radiation exposure, he or she will only receive one dose of the drug.

Patients receiving romiplostim, a TPO receptor agonist indicated for the treatment of chronic immune thrombocytopenia (ITP), should have a complete blood count, platelet count, and peripheral blood smear and have these values monitored at the start of treatment. Monitoring should continue throughout treatment and after discontinuation of treatment, and laboratory evaluations should be performed for at least two weeks after the patient stops treatment. Another new option for patients with ITP is eltrombopag, a non-peptide TPO receptor agonist that can be taken orally once daily on an empty stomach. Eltrombopag inhibits the organic anion transporting polypeptide OATP1B1 and can increase the level of the drug that is a substrate of this enzyme. Everyone’s constitution is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

RomiplostimThe original drug has been approved by the State Food and Drug Administration for marketing. Due to its short time on the market, it is not included in the scope of medical insurance. It may be difficult to purchase it domestically. The price of the original version in Hong Kong may be RMB 10,000 per pill (the price may fluctuate due to exchange rates). The price of the European version of romiplostim the original drug may be 11,000 RMB per pill, the German version may be 9,850 RMB per pill, and the Hong Kong version may be 8,900 RMB per pill (the price may fluctuate due to the exchange rate). The ingredients of the drugs are basically the same. For specific prices and drug details, please consult Yaode’s medical consultant.