Chinese instructions for Erlotinib

1. Indications: Erlotinib (Erlotinib) is an oral therapeutic drug suitable for adult patients who have been diagnosed with non-small cell lung cancer (NSCLC) and carry sensitive mutations in the epidermal growth factor receptor (EGFR) kinase region. Also used to treat pancreatic cancer.

2. Mechanism of action: Erlotinib is a tyrosine kinase inhibitor that inhibits the growth and spread of tumors by preventing the excessive activation of the EGFR signaling pathway in tumor cells. This is particularly important for patients who carry mutations in the EGFR kinase domain, as these mutations make cells overly dependent on activation of the EGFR pathway.

3. Pharmacology: Erlotinib is rapidly absorbed after oral administration and is mainly metabolized by the liver. CYP3Aenzyme is the main metabolic pathway and forms active metabolites. The drug and its metabolites are excreted via the kidneys.

4. Dosage and usage: Before using erlotinib, be sure to consult a doctor and strictly follow the doctor's recommendations and instructions. The doctor will develop a personalized medication plan based on your condition and individual characteristics. Non-small cell lung cancer: 150 mg orally, once daily on an empty stomach (at least one hour before or two hours after meals). Until the disease progresses or intolerable toxic side effects occur. For pancreatic cancer, take 100 mg orally on an empty stomach (at least one hour before or two hours after meals) once a day until the disease progresses or intolerable side effects occur.

5. Side effects: Erlotinib may cause a series of side effects, including but not limited to rash, diarrhea, nausea, fatigue, etc. Some patients may experience severe skin reactions, so skin conditions need to be monitored closely during use.

6. Warnings and precautions:

1.Monitoring and testing: During the use of erlotinib, liver function, electrocardiogram and pulmonary function must be monitored regularly. Regularly checkEGFRmutation status to ensure the effectiveness of the drug.

2.Skin protection: Use of erlotinib may cause rash. Avoid exposure to strong sunlight to reduce the risk of rash. If rash or other skin discomfort occurs, inform your doctor promptly.

3.Drug interactions: While using erlotinib, doctors should be informed of other drugs being used, especially drugs that affect CYP3Ametabolizing enzymes. Avoid concurrent use with medications that may interact to reduce the risk of adverse reactions.

4.Pregnant and lactating women: Pregnant and lactating women should not use erlotinib to prevent adverse effects on the fetus or infant.

5.Elderly patients and special groups: For elderly patients and patients with impaired liver function, the drug dosage may need to be adjusted, and doctors will make recommendations based on the patient's specific conditions. Dosage adjustments are usually not required in patients with impaired renal function.

6.Driving and operating machinery: Erlotinib may cause fatigue or other discomfort. Patients should pay attention to their own conditions when using the drug and avoid driving motor vehicles or operating dangerous machinery.

7. Contraindications: Erlotinib is contraindicated in patients who are allergic to the drug ingredients. Pregnant and breastfeeding women should also avoid using this drug to prevent adverse effects on the fetus or baby.

8. Drug interactions: While using erlotinib, be sure to inform your doctor of other drugs you are using, especially those that affectCYP3Ametabolizing enzymes. Avoid concurrent use with medications that may interact to reduce the risk of adverse reactions.

9. Medication for special groups:

1.For elderly patients and patients with impaired liver function, the dosage of the drug may need to be adjusted, and the doctor will make recommendations based on the patient's specific conditions.

2.Patients with impaired renal function usually do not require dose adjustment, but close monitoring is required during use.

10. Availability and price situation: Erlotinib has been launched in China and has been included in medical insurance. Patients can purchase it domestically, and the domestic price is approximately 700~1000Range, the specification is 150mg*7 tablets. Due to different medical insurance policies in different places, the price is also different. Please consult the local pharmacy or medical insurance bureau for details. Erlotinib abroad is mainly an Indian generic drug, with a price of about 900 yuan. The specifications are divided into 100mg*30 tablets and 150mg*30 tablets, which are about four times the domestic specifications, but the price is similar to that in China.