How long does it take for resistance to Entrectinib to develop?

Drug resistance is one of the common challenges in treating tumors. Entrectinib (Entrectinib), as a targeted therapy, may also cause resistance in some patients. However, the rate and duration of drug resistance development vary with individual patient differences and tumor characteristics, making it difficult to provide an exact timeline.

Entrectinib resistance may be the result of multiple factors, including gene mutations, signaling pathway variations, and tumor cell adaptability. Some studies suggest that resistance to entrectinib may develop over months or years, but some patients continue to benefit for longer.

It needs to be emphasized that drug resistance is a complex process that varies from patient to patient. Treatment decisions should be made under the guidance of a doctor, who will develop the most appropriate treatment plan based on the patient's condition and make adjustments based on the response and progress of the treatment. Early treatment and close monitoring are both important strategies to reduce the development of drug resistance.

Entrectinib has been launched in China, but due to its short time on the market, it has not yet been included in the medical insurance catalog. Since it has just been launched, it is difficult to purchase domestically and the price is very high. For specific prices, please consult the hospital pharmacy at that time. There are original drugs and generic drugs abroad. The original drugs abroad are mainly European versions of original drugs. The price is about 45,000 yuan. The price is relatively high and may be unaffordable for ordinary families. Generic drugs are mainly Lao generic drugs, with prices ranging from 4,000 to 8,000yuan, which are much cheaper than original drugs, and the ingredients of original drugs and generic drugs are basically the same.