Will taking Ripretinib for 3 months cure the disease?

Ripretinib is available as oral tablets and is only available by prescription. The recommended dose is 150 mg per day, taken at the same time each day. If side effects are intolerable, treatment may be suspended or the dose may be reduced to 100 mg per day. Treatment should continue as long as the patient is benefiting from it, otherwise side effects can become unmanageable.

In the study, the median progression-free survival in the repetinib group was 6.3 months, and the objective response rate was 9%. Responses in patients treated with repetinib were durable, with one in eight responders having progressive disease at the time of data cutoff. Additionally, more patients who received repetinib had stable disease and fewer patients had progressive disease at 12 weeks compared with patients who received placebo. It is worth noting that the majority of patients treated with repetinib had stable disease, and one of the most common treatment-related adverse events was alopecia, mainly grade 1 and 2.

The original drug of Ripetinib has been marketed in China and has been approved by the National Medical Insurance Bureau to enter the scope of Class B medical insurance, but it is limited to patients who meet the indications. The price of each box of 50mg*30 tablets may be around 30,000 yuan. The expensive price may increase the pressure on families with heavy financial burdens. The US version of Ripetinib Specifications50mg*90 tablets sold overseas may be priced around RMB 77,000 per box (the price may fluctuate due to exchange rates). The ingredients of foreign original drugs are basically the same as those of domestic original drugs. Currently, there is no generic drug of Ripetinib produced and marketed overseas. For specific prices and drug information, please consult Yaode’s medical consultant.