Can Rasagiline be stopped suddenly?

Rasagiline is not a controlled substance and studies in mice and rats have not identified any potential for drug abuse or dependence. Clinical trials have not shown any evidence of potential abuse, tolerance, or physical dependence; however, no systematic studies in humans have been conducted to evaluate these effects.

Patients with Parkinson's disease (PD) who take dopamine agonists can experience symptoms similar to withdrawal from addictive drugs. When they need to reduce the dose or discontinue these drugs, this is called dopamine agonist withdrawal syndrome (DAWS). The reasons for discontinuation are mainly related to significant side effects, such as hallucinations, cognitive changes, and impulse control disorders (ICD). Rasagiline can improve depressive symptoms in patients with new onset Parkinson's disease. This finding was confirmed by a post hoc exploratory analysis of the ADAGIO study, which showed that depression scores were better in PD patients taking rasagiline, suggesting a positive effect of rasagiline on affective non-motor symptoms.

The original drug of rasagiline has been launched in China and has entered the category of Class B medical insurance. The common name is rasagiline mesylate tablets, and the specifications areThe price of each box of 1mg*14 tablets may be around RMB 600. The price of the Turkish version of rasagiline's original drug, 1mg*30 tablets, per box sold overseas may be around RMB 310 (the price may fluctuate due to exchange rates). There are also generic drugs produced in other countries. The price of 1mg*100 tablets per box produced by Indian pharmaceutical factories may be around RMB 240 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of generic drugs are basically the same as those of domestic and foreign original drugs. For specific prices and drug information, please consult Yaode Medical Consultant.