Eteplirsen Chinese instructions

1. Indications: Eteplirsen (Eteplirsen) is suitable for patients with Duchenne muscular dystrophy. This drug is used to promote gene splicing of specific gene defects in certain DMD patients to improve dystrophin Protein production.

2. Mechanism of action: Tiplerisen is a nucleic acid drug that promotes the production of dystrophin protein by helping to restore DMD normal gene splicing of specific gene defects in patients. Dystrophin The protein is essential for the normal function of muscles, especially in muscle contraction and maintenance of muscle structure.

3. Pharmacology: Tiplerisen helps to restore the normal gene splicing process by matching the specific defective gene sequence present in the genome of DMD patients. This prompts muscle cells to produce more dystrophin protein, which can help reduce a patient's symptoms.

4. Dosage and usage: Use tiplisen in the appropriate dosage and usage as recommended by your doctor. Typically, tiplisen is given by intravenous infusion, with the specific dose and infusion frequency adjusted to the patient's weight, age, and clinical condition.

5. Side effects: Tiplerisen may cause some side effects, including but not limited to muscle pain, injection site reaction, vomiting, headache, etc. If any adverse reactions occur, your doctor should be informed immediately.

6. Warnings and Precautions

1.Dosing and monitoring should only be done by medical professionals.

2.During the use of drugs, conduct regular physical examinations and laboratory tests to monitor the efficacy and possible adverse reactions of the drugs.

3.If symptoms such as severe allergic reaction, difficulty breathing, or cardiac arrhythmia occur, seek medical attention immediately.

7. Contraindications: Those who are allergic to any of the ingredients of tiplisen are prohibited from using it. Also, patients with certain serious health problems should use it with caution and on the advice of their doctor.

8. Drug interactions: While using tiplisen , interactions with other drugs should be avoided, especially drugs that may affect heart function and liver metabolism. Doctor's advice should be sought before using other medications.

9. Medication for Special Populations

1.Children:Whether the use of tiplisen is safe and effective for children (including infants) should be determined according to the guidance of a doctor.

2.Pregnant and lactating women: During pregnancy and lactation, tiplicen should be used with caution and under the supervision of a doctor.

10. Availability and price situation: Tiplerisen has not yet been launched in China, so patients cannot purchase it domestically. There are only American original drugs abroad, and there are no generic drugs. The price is around 1,600 US dollars, but it is difficult to purchase.