Can Dapagliflozin be used in combination with metformin?

Dapagliflozin and metformin (Metformin) are two drugs commonly used to treat type 2 diabetes. They can be used together to achieve better blood sugar control. This combined strategy is widely used in clinical practice and is generally safe and effective.

Dapagliflozin is a drug that is a sodium glucose co-transporter2 (SGLT2) inhibitor. Its mechanism of action is to lower blood sugar levels by prompting the kidneys to discharge excess glucose. Metformin is an insulin sensitizer that can reduce the amount of glucose released by the liver while improving the ability of body cells to absorb and utilize glucose. The two drugs work in different ways, so using them together can work synergistically to help patients better control their blood sugar.

The combined use of dapagliflozin and metformin should be done under the supervision of a physician. The doctor will develop an individualized treatment plan based on the patient's diabetes status, blood sugar level, weight, kidney function and other factors. Generally, the combined use of these two drugs is safe, but there are some potential risks and precautions to consider.

One potential risk is hypoglycemia (low blood sugar). Metformin triggers the release of insulin, while dapagliflozin's mechanism of action does not involve insulin. When used together, the dose of metformin may sometimes need to be adjusted to reduce the risk of hypoglycemia.

Another factor to consider is adverse drug reactions. Dapagliflozin may cause side effects such as urinary tract infection and urinary tract infection, while metformin may cause gastrointestinal discomfort. When using these drugs, patients should pay close attention to their symptoms and have regular follow-up visits, and communicate with their doctors about their reactions in a timely manner.

Dapagliflozin has been launched in China and has been included in medical insurance. Patients can purchase it domestically. The domestic price is relatively cheap. Please consult the local hospital pharmacy or medical insurance bureau for specific prices and reimbursement policies.