Enfortumab Chinese version instructions

1. Indications: Ennosumab is a drug used to treat certain types of cancer, mainly for the treatment of advanced or metastatic urothelial carcinoma (urothelial carcinoma). Urothelial carcinoma is a common type of cancer that occurs in the bladder, renal pelvis, and urethra.

2. Mechanism of action: Ennosumab works by inhibiting the binding of Nectin-4 protein, which is overexpressed on the surface of urothelial cancer cells. The drug prompts the immune system to attack and destroy cancer cells, thereby slowing the growth and spread of tumors.

3. Pharmacology: Ennosumab is a chimeric monoclonal antibody that binds to the Nectin-4 protein and inhibits the survival signals and growth factor transmission of cancer cells. This helps slow tumor growth and improves the immune system's ability to attack cancer cells.

4. Dosage and usage: The dosage and frequency of ennosumab should be adjusted according to the doctor's recommendations. It is usually given to patients as an intravenous injection, and each course of treatment may last several weeks. The specific dosage and interval between courses should be followed as directed by the doctor.

5. Side Effects: Ennozumab may cause a series of side effects, including but not limited to nausea, vomiting, fatigue, diarrhea, skin reactions, etc. Serious side effects may include immune reactions, infections, and more. Patients should closely monitor side effects while using the drug and inform their doctor promptly.

VI. Warnings and Precautions: During the use of ennozumab, patients should pay close attention to any abnormal symptoms and undergo regular medical examinations. In the event of an emergency such as severe allergic reaction or difficulty breathing, seek medical attention immediately. Additionally, patients may need to avoid concurrent use with other immunotherapy drugs to reduce potential drug interactions.

7. Contraindications: Patients who are allergic to the components of ennozumab should not use this drug. In addition, in specific cases, doctors may consider whether to contraindicate the drug based on factors such as the patient's health and drug interactions.

8. Drug interactions: While taking ennozumab, patients should inform their doctor about other medications they are taking, including prescription drugs, over-the-counter drugs, and supplements. Certain medications may affect how well ennozumab works or increase the risk of side effects.

9. Medication for Special Populations: For special populations, such as pregnant women, lactating women, the elderly, etc., the use of ennosumab may require special attention. Before use, your doctor should be informed of relevant personal health information to determine whether the drug is suitable for use.

10. Listing and price situation: Ennosumab is not currently available in the country, so patients cannot purchase it domestically and need to purchase ennosumab through overseas channels. There are only enromonumab original drugs in foreign countries, and there are no generic drugs. They are mainly Japanese original drugs, and the price is more than 10,000 yuan.