Chinese instructions for Finerenone

1. Indications: Finelidone is a drug used to treat specific cardiovascular diseases. The indications are as follows:

1.For the treatment of patients with chronic heart failure (CHF) to reduce the risk of recurrence of heart failure.

2.For patients with type 2 diabetes to reduce the risk of kidney disease progression.

2. Mechanism of action: Fenelinone is a ketosterol receptor antagonist and works in the following ways:

1.Inhibits aldosterone receptors and reduces the effects of aldosterone on cardiovascular and kidneys.

2.Regulate body fluid balance and reduce the burden on the cardiovascular system.

3.Protect kidneys from damage by regulating inflammation and fibrosis processes.

3. Pharmacology: Fenelinone affects the role of aldosterone in the body by selectively antagonizing aldosterone receptors. It plays an important role in the cardiovascular system and kidneys, helping to maintain normal water and electrolyte balance and reduce the recurrence of heart failure and the progression of kidney disease by inhibiting the negative effects of aldosterone.

4. Dosage and usage

1.Medicines must be taken strictly in accordance with the doctor's prescription.

2.It is generally recommended to take it orally with meals to reduce stomach discomfort.

3.The recommended initial dose is 1 times a day, and the dose can be adjusted according to the condition.

4.Do not change the dose or stop taking the medicine on your own.

5. Side effects: Drugs may cause some side effects, common ones include but are not limited to:

1.Nausea, vomiting, diarrhea and other gastrointestinal discomforts.

2.Headache, dizziness, fatigue, etc.

3.Hyperkalemia (can cause arrhythmia, etc.).

4.Allergic reactions, such as rash, urticaria, etc.

6. Warnings and Precautions

1.Regular follow-up visits during medication to monitor renal function and electrolyte levels.

2.Pay attention to blood potassium levels and avoid high-potassium diet and medications.

3.Pregnant women, lactating women and women planning pregnancy should use it under the guidance of a doctor.

4.Regular fundus examinations may be required during long-term use.

7. Contraindications

1.Those who are allergic to fenelidone or drug ingredients.

2.Those with seriously elevated serum potassium.

3.Patients with severe renal insufficiency.

8. Drug interactions: When using fenelidone, you should pay attention to the following drug interactions:

1.Avoid simultaneous use with certain diuretics, angiotensin-converting enzyme inhibitors, etc., which may increase the risk of hyperkalemia.

2.Be sure to consult your doctor or pharmacist when using this product with other drugs.

9. Medication for Special Populations: Special populations such as the elderly, those with impaired liver function, and patients with specific chronic diseases should be cautious when using it, and the dosage needs to be adjusted according to the doctor's recommendations.

10. Availability and price situation: Fenelidone is currently on the market in China and has been included in medical insurance. Patients can purchase it at domestic hospital pharmacies. For specific prices and prices after medical insurance reimbursement, please consult the local hospital pharmacy. Overseas, the main Japanese original drug is fenelidone, with a specification of 10 mg *100 tablets of about 2,000 yuan, which is the same as the domestic original drug.