Common side effects and treatments of Pomalidomide

For patients taking Pomalidomide and the platelet count is less than 25000/mcL, the drug should be permanently discontinued. Permanently discontinue pomalidomide due to angioedema, anaphylaxis, grade 4 rash, flaking, blistering, or any other serious skin reaction. For other grade 3 or 4 toxicities, when the physician determines that the toxicity has dropped to ≤ grade 2, treatment is discontinued and restarted at a dose 1 mg less than the previous dose.

In patients with multiple myeloma (MM), the use of pomalidomide Common side effects include neutropenia, thrombocytopenia, etc., and the neutrophil count is at least 500/mcL, when the platelet count is at least 50,000/mcL, the patient should be started on a new cycle of pomalidomide treatment, which should be 1 mg less than the previous dose. In patients with Kaposi's sarcoma (KS), start a new round of pomalidomide therapy when the neutrophil count is at least 1,000/mcL and the platelet count is at least 75,000/mcL. If 1 mg once daily is not tolerated, permanently discontinue pomalidomide.

Pomalidomide, independently developed in China, has been launched domestically and has now entered the scope of medical insurance. The price of domestically produced Pomalidomide may be around RMB 4,000 per box, while the Turkish version sold overseas may be priced around RMB 15,000 per box (the price may fluctuate due to exchange rates), which is relatively expensive. There are also cheaper generic drugs produced in other countries overseas. The price of each box produced by a Lao pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs, domestically produced drugs and foreign original drugs are basically the same. For more drug information and specific prices, please consult Yaode Medical Consultant.