What should I do if I become resistant to Pomalidomide?

Pomalidomide was initially approved in combination with dexamethasone for the treatment of patients with relapsed/refractory multiple myeloma (rrMM) and ≥2 prior lines of therapy, including those with Pomalidomide, bortezomib, and dexamethasone (PVd) significantly prolonged progression-free survival compared with vascular dementia (PVd). 11.2 months vs. 7.1 months).

In patients with multiple myeloma or Kaposi's sarcoma, the mean apparent volume of distribution of pomalidomide at steady state (Vd/F) is between 62 and 138 L. After 4 days of 2 mg dosing once daily, the concentration of pomalidomide in the semen of healthy subjects was approximately 67% of the plasma concentration 4 hours after dosing. It is metabolized in the liver mainly by CYP1A2 and CYP3A4. When a patient becomes resistant to pomalidomide, doctors will consider adjusting the drug's dose or regimen, or combining it with other chemotherapy drugs or targeted therapy drugs to improve the therapeutic effect. However, everyone’s physique is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

Pomalidomide, independently developed in China, has been launched domestically and has now entered the scope of medical insurance. The price of domestically produced Pomalidomide may be around RMB 4,000 per box, while the Turkish version sold overseas may be priced around RMB 15,000 per box (the price may fluctuate due to exchange rates), which is relatively expensive. There are also cheaper generic drugs produced in other countries overseas. The price of each box produced by a Lao pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs, domestically produced drugs and foreign original drugs are basically the same. For more drug information and specific prices, please consult Yaode Medical Consultant.