How long can you live after taking Pomalidomide?

The approval of pomalidomide was based primarily on an open-label Phase III trial that enrolled patients with multiple myeloma (MM) who had relapsed or progressed despite a median of five prior lines of therapy. Participants were randomly assigned to 28-day cycles of pomalidomide plus low-dose dexamethasone or high-dose dexamethasone alone.

Pomalidomide is structurally related to thalidomide and lenalidomide. Its exact mechanism of action is unknown, but like other drugs in this class, it is thought to have antimyeloma, antiangiogenic, immunomodulatory, and stromal cell effects. Treatment in clinical trials is usually continued until disease progression or the patient develops unacceptable toxicity. After 10 months, the study found that pomalidomide and low-dose dexamethasone significantly improved response rate, progression-free survival, and overall survival compared with high-dose dexamethasone.

Pomalidomide, independently developed in China, has been launched domestically and has now entered the scope of medical insurance. The price of domestically produced Pomalidomide may be around RMB 4,000 per box, while the Turkish version sold overseas may be priced around RMB 15,000 per box (the price may fluctuate due to exchange rates), which is relatively expensive. There are also cheaper generic drugs produced in other countries overseas. The price of each box produced by a Lao pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs, domestically produced drugs and foreign original drugs are basically the same. For more drug information and specific prices, please consult Yaode Medical Consultant.