Chinese instructions for Fulvestrant

1. Indications: Fulvestrant (Fulvestrant) is an endocrine therapy drug, mainly used to treat hormone receptor-positive breast cancer, including:

1.Patients diagnosed with breast cancer for the first time

2.Advanced breast cancer patients who have received anti-estrogen therapy

2. Mechanism of action and pharmacology: Fulvestrant is an estrogen receptor antagonist that works through the following mechanisms:

1.Inhibits the degradation of estrogen receptors and reduces the number of receptors, thereby reducing the sensitivity of cancer cells to estrogen.

2.Block estrogen receptor signaling and inhibit the growth and proliferation of cancer cells.

3. Dosage and usage;Fulvestrant is usually administered by intramuscular injection, and each course of treatment includes two injections. During the initial treatment phase, it is recommended to inject once every two weeks, with a dose of 500mg per injection. After that, during the maintenance treatment phase, injections can be given every four weeks.

4. Side Effects:Fulvestrant may cause some side effects, including but not limited to:

1.Pain, swelling or erythema at the injection site

2.Nausea, vomiting, diarrhea and other gastrointestinal discomfort

3.Fatigue, headache, etc.

4.Increased risk of fracture

5.Vaginal bleeding or abnormal discharge

5. Warnings and Precautions:When using fulvestrant, you should pay attention to the following matters:

1.It can only be used under the supervision of medical professionals and strictly follow medical instructions.

2.It is prohibited for pregnant women and lactating women should weigh the pros and cons before using it.

3.Clinical monitoring will be carried out regularly during treatment, including liver function, bone density, etc.

4.Pay attention to possible drug interactions and confirm with your doctor the safety of other drugs.

6. Contraindications Fulvestrant may have the following contraindications:

1.Those who are allergic to drug ingredients

2.Pregnant women or those who may be pregnant

3.Patients with severe liver function abnormalities

7. Drug interactions:When using fulvestrant, the doctor should be informed of other drugs being used to avoid possible drug interactions.

8. Medication for Special Populations:Special populations such as elderly patients and patients with impaired liver function may require special medication adjustments or monitoring when using fulvestrant.

9. Launch and price situation: Fulvestrant injection has been launched in China and has been included in medical insurance. Patients can purchase it domestically. The price of domestically imported original drugs is around 5,000 to 6,000, while domestic drugs are slightly cheaper. For specific prices, please consult the local hospital pharmacy or the medical insurance bureau. There is only Fulvestrant's original drug abroad. The cheaper original drugs are mainly the Turkish original drug and the Indian version of the original drug. The price is around 1,000~2,000 yuan, and the ingredients and efficacy of the original drugs at home and abroad are the same.