How many boxes of pemigatinib should you take a month?

Pemigatinib (Pemigatinib) is approved to treat adults with cholangiocarcinoma that has spread or cannot be removed with surgery. n>Patients with FGFR2 gene fusions or other changes in the FGFR2 gene structure, and myeloid or lymphoid cancers that have relapsed or failed to respond to treatment andhave certain changes in the FGFR1 gene structure. This use is approved under the FDA's accelerated approval program.

The recommended dose of pemetinib is 13.5 mg orally daily for 14 days, followed by 7 days off treatment, in a 21-day cycle, with the duration of treatment until disease progression or unacceptable toxicity. PemetinibCommon doses are4.5mg*14, 9mg*14, 13.5mg*14< span> tablets, if calculated as 13.5mg*14 tablets, you may need to take about 2 boxes a month. However, if the patient develops adverse reactions after taking pemetinib, the doctor will need to adjust the drug dosage.

The original drug of pemetinib has been launched in China. Due to its short time on the market, it has not yet entered the scope of medical insurance. The price of each box of 4.5mg*14 tablets may be around 30,000 yuan, which is expensive. The price of the original pemetinib drug, 13.5mg*14 tablets, per box sold overseas may be around RMB 70,000 (the price may fluctuate due to exchange rates). There are also generic pemetinib drugs produced in other countries overseas. For example, the price of a box of 4.5mg*21 tablets produced by a Laos pharmaceutical factory may be around 3,000 yuan (the price may fluctuate due to the exchange rate). The price is relatively cheap. The pharmaceutical ingredients of the generic drugs are basically the same as those of the original drugs at home and abroad.