What is the difference between Gilteritinib and Venetoclax? Which one is better?

Gilteritinib (Gilteritinib) and venetoclax (Venetoclax) are two drugs used to treat hematological malignancies. They have different mechanisms of action and application fields. Determining which is better requires consideration of the patient's specific circumstances, including condition type, genetic mutation status, and clinical history. This article will delve into the features and applications of both medications to help you better understand their differences and options.

Gilteritinib (Gilteritinib):

Giritinib is a tyrosine kinase inhibitor mainly used to treat acute myeloid leukemia (AML), especially patients with FLT3-ITD or FLT3-TKD mutations. FLT3mutation is a common mutation in AML. It causes malignant cells to continue to divide and proliferate, making it a target for treatment.

The working mechanism of giritinib: inhibiting FLT3 signaling pathway: giritinib inhibits FLT3tyrosine The activity of acid kinase prevents the abnormal activation of the FLT3 signaling pathway, thereby reducing the proliferation and survival of AML cells.

Applications of giritinib:

1.First-line treatment: Giritinib has been approved for the first-line treatment of adult AML patients with FLT3 mutations.

2.Relapsed or refractory AML: It is also used in patients with relapsed or refractory AML.

Common side effects: Common side effects of giritinib include fatigue, nausea, vomiting, headache, fever, anemia, etc. But most patients tolerate these side effects.

Venetoclax (Venetoclax):

Venetoclax is a BCL-2 inhibitor, mainly used to treat chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). Its mechanism of action is different from that of giritinib, but it also achieves therapeutic effects by interfering with the survival and proliferation of abnormal cells.

The working mechanism of venetoclax: Inhibition of BCL-2 protein: Venetoclax inhibits BCL-2 protein, which is a protein that regulates cell apoptosis (self-destruction). Leukemia cells often evade apoptosis by overexpressing BCL-2, and venetoclax works by restoring the apoptotic mechanism, prompting the death of these leukemia cells.

Applications of Venetoclax:

1. CLLTreatment: Venetoclax has been approved for the treatment of CLL, especially in high-risk patients with 17p deletions or TP53 mutations.

2. AMLTreatment: It is also used in the treatment of AML, especially in patients with IDH1/IDH2 mutations or TP53 mutations.

Common side effects:

Common side effects of venetoclax include low white blood cell count, fever, fatigue, nausea, and vomiting. As with giritinib, most patients tolerate these side effects.

Differences and options:

To determine which is better, giritinib or venetoclax, you need to consider the following factors:

1.Type of disease: First of all, it is necessary to clarify whether the patient is suffering from AML or CLL, because the indications of the two drugs are different.

2.Mutation status: For AML patients, it is important to understand the mutation status of genes such as FLT3, IDH1/IDH2 and TP53. Giritinib is mainly suitable for FLT3 mutations, while venetoclax is also used in different mutations.

3.Clinical history: The patient’s treatment history and previous medications may also influence the choice. Some patients may have already received giritinib or venetoclax and will need treatment adjustments based on previous response and tolerability.

4.Patient health: The patient’s overall health, age and other comorbidities also influence the choice. Certain side effects may be more significant in some patients and require careful consideration.

5.Treatment goals: Finally, treatment goals are also important. Whether to pursue symptom relief, improve survival rates, or pursue treatment options such as bone marrow transplantation will also affect drug selection.

In summary, giritinib and venetoclax are two drugs with different mechanisms of action, and they have different applications in different leukemia types and gene mutation states. Which one is better depends on the individual patient's situation and usually needs to be decided by the clinician based on detailed condition and patient characteristics. It is important that patients receive treatment under the guidance of a professional doctor and have regular follow-up visits to monitor treatment effects and side effects. During treatment, patients should also actively participate in health management and maintain good lifestyle and dietary habits to improve treatment effects and quality of life.

Giritinib is currently on the market in China, but it is not included in medical insurance. If patients need it, they can go to the hospital to buy it at their own expense, but the price is very high, about 35,000 yuan. For specific prices, please consult the local hospital pharmacy. Foreign original drugs of gilitinib are even more expensive. For example, the price of the Hong Kong version of the original drug is around 90,000 yuan, and the European version of the original drug is as high as more than 200,000 yuan, which is simply unaffordable for ordinary patients. There are already foreign generic drugs of Giritinib on the market, mainly Laos generic drugs. The price is about four to five thousand yuan, which is relatively cheap. In terms of drug ingredients, the ingredients of domestic and foreign original gilitinib drugs are basically the same as those of generic drugs.

Venetoclax has been launched in China, but it is not included in medical insurance, so the price is relatively high. The current domestic price of venetoclax is about 5,000 yuan for 100 mg*14 tablets. The price is very high and difficult for ordinary families to accept. Venetoclax abroad includes original drugs and generic drugs. The price of original drugs is also relatively high, while the generic drugs are relatively cheap. For example, the Bangladeshi versionVenetoclaxGenericPharmaceutical specifications100mg*120The price of tablets is 4500~5 000yuanaround,the price of generic drugs in Laos is around4300~5000yuan. The price of generic drugsis relativelycheapermany, and the drug ingredients are the same as the original drugs.