How many years should you take Pralsetinib?

The duration of use of Pralsetinib (Pralsetinib) should be determined on a case-by-case basis for each patient. In clinical trials, treatment cycles with platinib are usually continued until disease progression occurs or the drug's side effects become intolerable. For those patients who experience significant benefit, physicians may continue to recommend platinib as part of long-term treatment.

The response rate of platinib shown in experiments with RET-positive non-small cell lung cancer is about 70%, the median duration of response is about 2 years, and the disease control rate in patients who have previously received chemotherapy is 91%. However, platinib has some myelosuppression, such as neutropenia, and less than 1% of patients stopped treatment due to neutropenia and only reduced the dose. It comes in 100 milligram tablets, you start with 40 milligrams and use it at lower doses and so on, and there was one patient in the study who had a central nervous system reaction that lasted for several years, even with a reduced dose. Therefore, doctors will develop the most appropriate treatment plan based on the specific situation and regularly evaluate the effectiveness and tolerability of the drug.

It is understood that the original drug Platinib has been launched in China, but it has not yet entered the scope of medical insurance. The price of each box of 100mg*120 tablets may be around 60,000 yuan, which is expensive. The price of the European version of 100mg*60 capsules sold overseas may be around 40,000 yuan per box, and the price of the American version may be around 150,000 yuan per box (prices may fluctuate due to exchange rates). The ingredients of domestic and foreign original drugs are basically the same. There is currently no generic version of Platinib available on the market. Please consult your medical consultant for specific prices and drug details.