What are the side effects of lxazomib?

Ixazomib is an oral drug used to treat multiple myeloma (Multiple Myeloma). Although it is an effective treatment, like any drug, ixazomib may cause some side effects. Common side effects and potential risks of ixazomib are detailed below.

1. Nausea and Vomiting: Nausea and vomiting are one of the most common side effects of ixazomib. These symptoms usually appear within the first few days after starting treatment, but can be managed by taking preventive medications or with the advice of a doctor. Splitting the dose of ixazomib may also help reduce these symptoms.

2. Diarrhea: Diarrhea is another common side effect that may occur during treatment. It is important to maintain a good fluid and electrolyte balance to avoid dehydration. If diarrhea persists or worsens, patients should inform their doctor promptly so that appropriate measures can be taken.

3. Fatigue: Fatigue is a common symptom in patients with multiple myeloma and may be aggravated by the use of ixazomib. Patients may experience ongoing physical exhaustion and mental fatigue. Rest and moderate physical activity can help relieve these symptoms.

4. Anemia and thrombocytopenia: Ixazomib may cause anemia (decreased hemoglobin levels) and thrombocytopenia (decreased platelet count). This increases the patient's risk of becoming tired and prone to bruising. Regular blood tests will help monitor these changes and intervene if necessary, such as blood transfusions or adjustments to medication doses.

5. Dyspnea and throat swelling: A small number of patients may experience dyspnea and throat swelling while taking ixazomib. This may indicate a severe allergic reaction that requires immediate medical attention. Patients should contact their doctor or go to the emergency room immediately.

6. Skin reactions: Some patients may experience skin reactions such as rash, itching, or dry skin during use of ixazomib. These symptoms are usually mild, but if significant skin problems occur, patients should speak to their doctor for advice.

7. Dry mouth and oral problems: Dry mouth and oral problems such as stomatitis (inflammation within the mouth) may occur while using ixazomib. Maintaining oral hygiene and regular oral care can help alleviate these problems.

8. Renal insufficiency: Ixazomib may have a certain impact on the kidneys, leading to renal insufficiency. Therefore, doctors usually monitor kidney function regularly during treatment to make sure no serious problems occur. Patients should ensure adequate fluid intake to help maintain kidney function.

9. Neurotoxicity: Although ixazomib is less neurotoxic than some other treatments, in some cases patients may still experience peripheral neuropathy. This may manifest as paresthesia, numbness, tingling, or loss of balance. Patients should monitor these symptoms closely and report them to their doctor.

10. Other side effects: In addition, there are other possible side effects, such as headache, abdominal discomfort, loss of appetite, musculoskeletal pain, etc. Although these side effects are usually mild, they still need to be paid attention to.

The original drug of Ixazomib has been launched in China and has been included in medical insurance. Patients can purchase it domestically, but the price is still relatively high. The price is about 15,000 to 6,000 yuan. For specific prices and medical insurance reimbursement policies, please consult the local hospital pharmacy or medical insurance bureau. Foreign original drugs are even more expensive. The cheaper foreign ones are ixazomib generics, mainly Laotian generics. The price is more than 1,000 yuan, and the ingredients of the original drugs and generic drugs are basically the same.